Results 101 to 110 of about 1,564,254 (214)

Epigenetic blind spots – the role of DNA methylation dynamics in stem cell‐based models of embryogenesis

open access: yesFEBS Letters, EarlyView.
Embryo‐like structures (stembryos) are an innovative tool, but they are hindered by experimental variability and limited developmental potential. DNA methylation is crucial for mammalian development, but its status in stembryo models is poorly characterized.
Sara Canil   +4 more
wiley   +1 more source

pH‐mediated activation of the lysosomal arginine sensor SLC38A9

open access: yesFEBS Letters, EarlyView.
Cells monitor nutrient levels via the lysosomal transporter SLC38A9 to activate the mechanistic target of rapamycin complex 1 (mTORC1). This study reveals that SLC38A9 function is regulated by pH. We identified histidine 544 as a critical pH sensor that undergoes conformational changes to control amino acid efflux from lysosomes; therefore, it ...
Xuelang Mu, Ampon Sae Her, Tamir Gonen
wiley   +1 more source

RETHINKING THE BUSINESS PROCESS THROUGH REENGINEERING [PDF]

open access: yes
Rethinking business through reengineering is based on the assumption that to meet contemporary demands of quality, service, flexibility, and low cost, processes must be kept simple.
Pompiliu Constantinescu   +3 more
core  

Starting the Indigenisation Process of Social Work Practice in Malaysia

open access: yesSocial Work and Society, 2020
This study focuses on the extent to which social work practice in Malaysia can be indigenised. The social work programmes and practices needs to accommodate the traditions and sociocultural practices of the people to provide adequate and relevant ...
Adam Andani Mohammed   +2 more
doaj   +2 more sources

OVERSEEING THE PARALLEL PROCESS IN SOCIAL WORK

open access: yesInternational Journal of Social and Educational Innovation
The parallel process has been and continues to be a controversial topic of interest in psychotherapy, and has been extended to social work supervision. The aim of the paper is to provide some guidelines for the supervisor and the supervisee to intervene
Loredana-Ileana VÎȘCU, Marius MARICI
doaj  

Residual tail twisting in ascidian larvae is stabilized by asymmetric myofibrils that resist bilateral symmetry restoration

open access: yesFEBS Letters, EarlyView.
Ascidian Ciona larvae initially show strong clockwise tail twisting, which is largely corrected during development. However, a small residual twist remains. This study shows that organized helical myofibrils in tail muscles mechanically stabilize this residual asymmetry, preventing complete restoration of bilateral symmetry and revealing how embryos ...
Yuki S. Kogure   +3 more
wiley   +1 more source

Work process knowledge and organisational learning

open access: yes, 2003
The transfer and improvement of Work Process Knowledge (WPK) are the goals of two chemical companies studied in a European research project in which measures of Organisational Learning were thoroughly ...
Röben P., MARIANI, Michele
core  

Biophysical approaches for studying viral entry

open access: yesFEBS Letters, EarlyView.
Viruses infect all living organisms and have been responsible for major epidemics and pandemics. Their ongoing evolutionary battle with host defenses creates a constant need for improved tools to study viral behavior. Advancing methods to probe viral attachment, fusion, and genome release deepen our understanding of how infections begin and support the
Inbar Yosibash, Raya Sorkin
wiley   +1 more source

Generic Process Transformation Model: Transition to Process-based Organization [PDF]

open access: yes
The competitive global market climate of the new millennium has raised awareness of business processes as the most important management paradigm (Levi, 2002).
Tomislav Hernaus
core  

Building boundaries and negotiating work at home

open access: yes, 2001
Millions of people are now working full-or part-time at home. Computer technology allows workers remote access to materials and facilitates communication with coworkers and supervisors.
Christine Salazar, Salazar, Christine
core   +1 more source

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