Results 81 to 90 of about 1,564,254 (214)

The planar cell polarity protein Vangl2 interacts with the PDZ‐domains of Scribble but not with a unique PDZ‐like domain in Inturned

FEBS Letters, EarlyView.
Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes, Jan Brysch, Carmen Gelze, Lilli Meier, Daniel Kümmel   +4 more
wiley   +1 more source

Why Students Choose Social Work?

, 2018
University and college that organize the education of social workers and social welfare, give a chance for Indonesia to produce professional practitioners in social worker sector to be much better.
Prayuda, A. (Akbar), Nurdin, Fadhil, Nurdin, F. (Fadhil), Prayuda, Akbar   +3 more
core   +1 more source

MODEL SIMULASI KINERJA PRODUKSI TEH UNTUK MINIMISASI WORK-IN-PROCESS

Jurnal Optimasi Sistem Industri, 2010
Simulasi komputer adalah salah satu cara yang digunakan untuk menganalisis suatu sistem dengan cara memodelkannya menggunakan software komputer. Dengan menggunakan simulasi kita dapat melihat secara langsung proses kerja dari sistem.
Agus Wibowo, Demi Ramadian
doaj   +1 more source

Tau acetylation at K331 has limited impact on tau pathology in vivo

FEBS Letters, EarlyView.
We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto, Yukio Matsuba, Mika Takahashi, Takaomi C. Saido   +3 more
wiley   +1 more source

Visual support for work assignment in process-aware information systems: Framework formalisation and implementation

, 2012
Process-aware information systems, ranging from generic workflow systems to dedicated enterprise information systems, use work-lists to offer so-called work items to users. In real scenarios, users can be confronted with a very large number of work items
Arthur H. M. ter Hofstede, Aalst, WMP Wil van der, Adams, Michael J., Adams, M., Adams, M, Aalst, van der, W.M.P., ter Hofstede, Arthur H.M., Leoni, de, M., Wil M. P. van der Aalst, Hofstede, ter, A.H.M., Michael Adams, Leoni, M Massimiliano de, van der Aalst, Wil M.P., DE LEONI, MASSIMILIANO, Hofstede, AHM Arthur ter   +14 more
core   +1 more source

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Visual fatigue during control room work in process industries

, 2020
BACKGROUND: Working in front of computer screens is visually demanding and related to adverse eye symptoms. Occurrence of glare further increases visual fatigue.
Österman, Cecilia,, Glimne, Susanne, Brautaset, Rune, Glimne, Susanne,, Brautaset, Rune,, Österman, Cecilia   +5 more
core   +1 more source

The Dynamics of Dignity at Work [PDF]

, 2016
Randy Hodson's categories offer an ambitious, comprehensive framework for analysing the objective and subjective conditions that shape dignity and resistance at work. In this chapter, we engage with Hodson and his collaborators work through exploring its
Thompson, Paul, Paul Thompson, Newsome, Kirsty, Kirsty Newsome   +3 more
core   +1 more source

Structural insights into an engineered feruloyl esterase with improved MHET degrading properties

FEBS Letters, EarlyView.
A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa, Konstantinos Makryniotis, Theofani‐Iosifina Sousani, Evangelos Topakas, Vangelis Daskalakis, Maria Dimarogona   +5 more
wiley   +1 more source

Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system

FEBS Letters, EarlyView.
Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley   +1 more source