Results 131 to 140 of about 18,932,662 (328)

Structural instability impairs function of the UDP‐xylose synthase 1 Ile181Asn variant associated with short‐stature genetic syndrome in humans

open access: yesFEBS Letters, EarlyView.
The Ile181Asn variant of human UDP‐xylose synthase (hUXS1), associated with a short‐stature genetic syndrome, has previously been reported as inactive. Our findings demonstrate that Ile181Asn‐hUXS1 retains catalytic activity similar to the wild‐type but exhibits reduced stability, a looser oligomeric state, and an increased tendency to precipitate ...
Tuo Li   +2 more
wiley   +1 more source

Professores em transição: produção de significados em atuação inicial na inclusão escolar

open access: yesPsicologia: Teoria e Pesquisa
RESUMO Analisamos a produção de significados em posicionamentos docentes em relação a práticas virtuosas em contexto inclusivo, realizando-se estudo de caso de professora em experiência inicial na inclusão, com quatro sessões de entrevistas ...
Gabriela Sousa de Melo Mieto   +2 more
doaj   +1 more source

Application of Photoelasticy for Study of Lamellar Cracks. [PDF]

open access: yes, 2013
In rolled sheets, non–metallic inclusions are distributed along the thickness of the sheet as narrow lines running parallel to the rolling direction. Such inclusions are the nuclei of lamellar cracks.
Jaroniek, Mieczysław   +1 more
core  

Cell wall target fragment discovery using a low‐cost, minimal fragment library

open access: yesFEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan   +5 more
wiley   +1 more source

Inclusion of Women in the Mining Sector: Challenges and Opportunities Through Education

open access: yesEducation Sciences
Labor dynamics have changed in recent years, and women have increased their participation in various activities within the production and business industries.
Selene Castañeda-Burciaga   +4 more
doaj   +1 more source

On the independent subsets of powers of paths and cycles

open access: yes, 2012
In the first part of this work we provide a formula for the number of edges of the Hasse diagram of the independent subsets of the h-th power of a path ordered by inclusion. For h=1 such a value is the number of edges of a Fibonacci cube.
Codara, Pietro, D'Antona, Ottavio M.
core  

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

open access: yesFEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee   +3 more
wiley   +1 more source

Dynamiques ségrégatives

open access: yesLa Nouvelle Revue du Travail
Faced with the democratic ideal of fluidity and social diversity in modern societies, the concept of segregation seems inappropriate, so much so that it refers to a past that is considered obsolete or undesirable.
Vincent-Arnaud Chappe   +2 more
doaj   +1 more source

Structural biology of ferritin nanocages

open access: yesFEBS Letters, EarlyView.
Ferritin is a conserved iron‐storage protein that sequesters iron as a ferric mineral core within a nanocage, protecting cells from oxidative damage and maintaining iron homeostasis. This review discusses ferritin biology, structure, and function, and highlights recent cryo‐EM studies revealing mechanisms of ferritinophagy, cellular iron uptake, and ...
Eloise Mastrangelo, Flavio Di Pisa
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

open access: yesFEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source

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