FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source
Translations of the Practice Environment Scale of the Nursing Work Index: A systematic review. [PDF]
Nurs Health Sci, 2023 Lake ET +4 more
europepmc +1 more source
Assessment of the Work Ability Index among Iranian Employees: A Systematic Review
تحقیقات سلامت در جامعه, 2022 Introduction and purpose: The ability to work is one of the important factors in predicting the working conditions, well-being, and health status of employees.
Haji Omid kalteh +4 more
doaj
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Work Ability Index of Forestry Machine Operators and some Ergonomic Aspects of their Work
Croatian Journal of Forest Engineering, 2013 This paper provides the results of an applied research of forestry machine operators related to their work ability index (WAI) and some ergonomic aspects of their everyday work. A questionnaire on work environment and working ability was conducted in the
Ivan Martinić +3 more
doaj
Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential
FEBS Letters, EarlyView.Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta +3 more
wiley +1 more source
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Prognostic Relevance of Global Myocardial Work Index in Patients with Moderate Aortic Valve Stenosis. [PDF]
J Clin Med, 2023 Kandels J +3 more
europepmc +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Translation and validation study of the Indonesian version of the practice environment scale of the nursing work index. [PDF]
Int J Nurs Sci, 2023 Juanamasta IG +4 more
europepmc +1 more source