Results 121 to 130 of about 4,285,820 (314)

Modulation of Homer1 EVH1 domain internal dynamics by putative autism‐associated mutations

FEBS Letters, EarlyView.
The putative autism‐associated M65I and S97L variants of the EVH1 domain of the postsynaptic scaffold protein Homer1 do not exhibit substantial changes in their overall structure or partner binding. Both of them, but especially the M65I variant, show altered internal dynamics relative to the wild‐type domain on the μs‐ms timescale, indicated by the ...
Fanni Farkas, Brigitta Maruzs, Zsófia E. Kálmán, Tomas Klumpler, Gyula Batta, Bálint Péterfia, Zoltán Gáspári   +6 more
wiley   +1 more source

The ubiquitin‐proteasome system and autophagy as guardians of the cellular proteome

FEBS Letters, EarlyView.
This Perspective covers the three principles governing the crosstalk between the ubiquitin‐proteasome system and autophagy in cellular proteostasis: (1) a shared ubiquitin code routing substrates via shuttle factors or autophagy receptors; (2) spatial compartmentalization into phase‐separated degradation hubs and organelle‐specific modules (exemplified
Ivan Dikic
wiley   +1 more source

Pediatric trauma patients in Swedish ambulance services -a retrospective observational study of assessments, interventions, and clinical outcomes

Scandinavian Journal of Trauma, Resuscitation and Emergency Medicine
Background Pediatric trauma patients constitute a significant portion of the trauma population treated by Swedish Emergency Medical Services (EMS), and trauma remains a notable cause of death among Swedish children.
Glenn Larsson, Sanna Larsson, Viktoria Strand, Carl Magnusson, Magnus Andersson Hagiwara   +4 more
doaj   +1 more source

An unexpected alternative viologen electron mediator site in tungsten‐containing formate dehydrogenase

FEBS Letters, EarlyView.
An unexpected alternative interaction site for ethyl viologen was identified in formate dehydrogenase 1 from Methylorubrum extorquens. Combined mutagenesis, kinetic analysis, and docking revealed that aromatic residues near an iron–sulfur cluster enable flavin mononucleotide‐independent electron transfer, offering a framework for engineering improved ...
Eleni G. Poloniataki, Yong Hwan Kim
wiley   +1 more source

“Live Social Work” : How to Bring Life Back into Social Work

, 2015
In this article I discuss how professional social work can entail critical, reflexive work. This is accomplished by adapting the concept of “live sociology”.
Herz, Marcus
core  

“We need to accept our limited resources”: a qualitative study exploring ambulance clinicians’ experiences of working conditions when caring for patients with breathlessness

BMC Emergency Medicine
Background Breathlessness is a common and potentially life-threatening symptom among patients and constitutes a frequent reason for ambulance dispatches.
Wivica Kauppi, Karl Hedman, Hanna Maurin Söderholm, Magnus Andersson Hagiwara   +3 more
doaj   +1 more source

Cell geometry and membrane protein crowding constrain Escherichia coli growth rate, overflow metabolism, respiration, and maintenance energy

FEBS Letters, EarlyView.
The physical dimensions and shape of bacterial cells define the surface area available to acquire nutrients and the volume available for synthesizing proteins and DNA. Here, we use computational systems biology to decode the importance of cell geometry as a major determinant of prokaryotic phenotype, including growth rate and metabolic efficiency. This
Ross P. Carlson, Tomáš Gedeon, Mauricio Garcia Benitez, Campbell Putnam, William R. Harcombe, Radhakrishnan Mahadevan, Ashley E. Beck   +6 more
wiley   +1 more source

Work/Life Balance - Learning Package

, 2011
This Learning Activity provides an introduction to the topic of work/life balance. It will establish the importance of a good work/life balance relationship in life.
EVOLUTION, UCLAN, Caroline Holliday, E-EVOLVE, UCLANOER   +4 more
core  

Patient–Registered Nurse Communication: Exploring Patients' Expectations and Experience in Primary Care Consultations

Health Expectations
Introduction Primary care is the first point of contact for patients in most Western healthcare systems, addressing acute, chronic and preventive health needs.
Sofia Östensson, Mariela Acuña Mora, Laura Darcy, Lotta Saarnio Huttu, Sandra Van Dulmen, Annelie J. Sundler   +5 more
doaj   +1 more source

Electron transfer between complexes III and IV in S. cerevisiae mitochondrial membranes

FEBS Letters, EarlyView.
Mitochondrial oxidative phosphorylation in S. cerevisiae mitoplasts is limited by complex IV catalytic capacity, rather than two‐dimensional cytochrome c diffusion. At physiological cytochrome c : supercomplex ratios at salinity equivalent to that of 20 mm monovalent salt, activity is maximized, indicating that this low ionic strength accurately mimics
Ana Paula Lobez, Mikael Oliveberg, Peter Brzezinski   +2 more
wiley   +1 more source