Results 251 to 260 of about 4,290,560 (312)

Overview of molecular signatures of senescence and associated resources: pros and cons

FEBS Open Bio, EarlyView.
Cells can enter a stress response state termed cellular senescence that is involved in various diseases and aging. Detecting these cells is challenging due to the lack of universal biomarkers. This review presents the current state of senescence identification, from biomarkers to molecular signatures, compares tools and approaches, and highlights ...
Orestis A. Ntintas, Sylvia Vagena, Pavlos Pantelis, Giorgos Theocharous, Russel Petty, Konstantinos Evangelou, Vassilis G. Gorgoulis   +6 more
wiley   +1 more source

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

Down‐regulation of Shh in the hair follicles of mice during chemotherapy‐induced hair loss is mediated by the JAK/STAT1 signaling pathway

FEBS Open Bio, EarlyView.
We found that during chemotherapy‐induced alopecia (CIA), Sonic hedgehog (Shh) expression significantly decreased in hair follicle Shh+ cells, whereas the Janus‐activated kinase/signal transducer and activator of transcription 1 (JAK/STAT1) signaling pathway was markedly activated.
Ruifang Fan, Jingling Huang, Xiang Lin, Tingjiao Lan, Yuli Tang, Ling Sun, Guixuan Zhou   +6 more
wiley   +1 more source

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Participation in Strategy Work

2015
Introduction This chapter examines participation in strategy research in general and in strategy-as-practice research in particular. Participation is arguably a key issue in strategy process research because it helps to create commitment to strategies, and its absence may have a negative impact on the quality of decision-making (Floyd and Wooldridge ...
Pikka-Maaria Laine, Eero Vaara
openaire   +5 more sources

Old Age Work Participation

2015
To understand how to raise labor force participation of older workers, it is necessary to understand demand, supply, and institutional factors. Labor supply and retirement decisions of older workers are at the core of microeconomic research and many countries have recently reformed their pension systems to make early retirement financially less ...
Zaidi, A., van Soest, Arthur
openaire   +2 more sources

Working With Participants

2019
Involving users in the design and evaluation of websites is one of the keys to ensuring they are accessible to as wide a range of people as possible. In this chapter, we present the core barriers and solutions that are often encountered by participants in user research activities that are undertaken as part of modern user-centred design processes.
Christopher Power, Helen Petrie
openaire   +1 more source

Classroom participation: Teachers’ work as listeners

Journal of Curriculum Studies, 2022
This article examines teachers’ work as part of the everyday life of classrooms, schools and communities—as curriculum design, dynamic pedagogies and as an oeuvre which is assembled over time. One of the hardest aspects of the everyday work of teachers, and perhaps one of the most under-rated and under-studied, is listening, really listening.
Barbara Comber, Debra Hayes
openaire   +2 more sources

Work Participation of Autistic Adolescents

Intellectual and Developmental Disabilities
Abstract This study sought to compare frequency of paid work by autistic adolescents to paid work by adolescents with other neurodevelopmental disorders and typically developing adolescents, and to examine whether demographic and clinical characteristics were associated with autistic adolescent employment with data from 2016–2019 ...
Michelle, Menezes, Jessica, Pappagianopoulos, Micah O, Mazurek   +2 more
openaire   +2 more sources