Results 71 to 80 of about 2,987,585 (255)

Engineered extracellular vesicles enriched with the miR‐214/199a cluster enhance the efficacy of chemotherapy in ovarian cancer

Molecular Oncology, EarlyView.
Loss of the miR‐214/199a cluster is associated with recurrence in ovarian cancer. Engineered small extracellular vesicles (m214‐sEVs) elevate miR‐214‐3p/miR‐199a‐5p in tumor cells, suppress β‐catenin, TLR4, and YKT6 signaling, reprogram tumor‐derived sEV cargo, reduce chemoresistance and migration, and enhance carboplatin efficacy and survival in ...
Weida Wang, Ayesha Alvero, Yi Qin, Mingjin Wang, Alexandra Fox, Yanfeng Li, Michael Millman, Amy Kemper, Gil Mor, Xian Shuang Liu, Michael Chopp, Zheng Gang Zhang, Yi Zhang   +12 more
wiley   +1 more source

Interrogating the immune landscape of microsatellite stable RAS‐mutated colon cancer

Molecular Oncology, EarlyView.
COLOSSUS project RAS‐mutated MSS colon cancer study explored transcriptomics and immune cell density by immunohistochemistry (IHC), Immunoscore (IS), ISIC/TuLIS scores, mutation counts, and detected different prevalences but similar microenvironment composition across immune markers with clinical relevance for future immunotherapy combination ...
Rodrigo Dienstmann, Eduardo García‐Galea, Alice O'Farrell, Zak Kinsella, Maxime Meylan, Florent Petitprez, Ingrid Arijs, Tom Venken, Hari Ps, Adrian Lärkeryd, Ian Miller, Janick Selves, Nadja Meindl‐Beinker, Fiorella Ruiz‐Pace, Elena Élez, Raquel Comas‐Navarro, Frank Lincoln, Dirk Fey, Gift Nyamundanda, Aoife Nolan, Joern Lewin, Raquel Perez‐Lopez, Jonathan Briody, Kathleen Bennett, Walter Kolch, David Matallanas, Alexander Kel, Enrique Arenas, Joaquín Arribas, Bart Ghesquière, Josep Tabernero, Julie Meilleroux, Deborah McNamara, Ray McDermott, Marvin Lim, Mary O'Reilly, Brian Bird, Lisa Stack, Lucia Moloney, Patrick Morris, Keith Egan, Maciej Milewski, Lars Scheuer, Joachim Behringer, Georg Bolz, Ramon Salazar, Cristina Santos, Andrea Ruiz, Orla Casey, Verena Murphy, Matthias Ebert, Livio Trusolino, Diether Lambrechts, Anguraj Sadanandam, Catherine Sautès‐Fridman, Jochen Prehn, Paolo Nuciforo, Jacques Fieschi, Florence Monville, Darran O'Connor, Wolf Fridman, Annette Byrne   +61 more
wiley   +1 more source

Hybrid adaptive Wolf-Particle swarm optimization algorithm and its application in CNN neural network hyperparameters optimization

Discover Computing
This paper introduces the Hybrid Adaptive Wolf-Particle Swarm Optimization (HAWPSO) algorithm, a novel metaheuristic framework designed to address the intricate challenge of optimizing hyperparameters in convolutional neural networks (CNNs) within ...
Keyin Chen, Jinzhen Xie
doaj   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

Molecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni, Antonella Palmese, Stefano Scalera, Laura Cipriani, Davide Mascolo, Patrizia Vici, Teresa Arcuri, Lorena Filomeno, Eriseld Krasniqi, Giovanni Blandino, Giulia Bon, Marcello Maugeri‐Saccà   +11 more
wiley   +1 more source

Data analysis evidence beyond correlation of a possible causal impact of weather on the COVID-19 spread, mediated by human mobility

Scientific Reports
Previous correlative and modeling approaches indicate influences of environmental factors on COVID-19 spread through atmospheric conditions’ impact on virus survival and transmission or host susceptibility.
Denis-Răducu Nichita, Mihai Dima, Loredana Boboc, Marian-Gabriel Hâncean   +3 more
doaj   +1 more source

Les Lumières Écossaises et le roman philosophique de Descartes [PDF]

, 2000
The paper reconstructs the reception of Descartes's work by the Scottish Enlighteners, from Colin MacLaurin to Dugald Stewart. The Scots' image of Descartes was a byproduct of a scientific controversy; philosophical arguments were brought into
Cremaschi, Sergio Volodia Marcello
core   +2 more sources

New-Physics Effects on Triple-Product Correlations in Lambda_b Decays

, 2002
We adopt an effective-lagrangian approach to compute the new-physics contributions to T-violating triple-product correlations in charmless Lambda_b decays. We use factorization and work to leading order in the heavy-quark expansion.
A. Datta, A.Y. Smirnov, Alakabha Datta, B.C. Allanach, C.E. Carlson, D.K. Ghosh, David London, E. Nardi, G. Hiller, G. Valencia, H.Y. Cheng, I. Hinchliffe, J. Bernabéu, K. Hagiwara, K. Leroux, M. Gronau, S. Pakvasa, W. Bensalem, W. Bensalem, Wafia Bensalem, Y. Grossman, Y. Grossman, Y. Nir   +22 more
core   +1 more source

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

Molecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu, Xixi Lin, Emil Mladenov, Veronika Mladenova, Jürgen Thomale, Ali Sak, Yao Wang, Yunxuan Deng, Eleni Gkika, Martin Stuschke, George Iliakis   +10 more
wiley   +1 more source

Searching for New Physics in $D^0\rightarrow \mu^+\mu^-,\; e^+e^-, \;\mu^{\pm}e^{\mp}$ at BES and/or Super Charm-Tau Factory

, 2014
In contrast with $B^0-\bar B^0$, $B_s-\bar B_s$ mixing where the standard model (SM) contributions overwhelm that of new physics beyond standard model (BSM), a measured relatively large $D^0-\bar D^0$ mixing where the SM contribution is negligible ...
Jia, Lian-Bao, Ke, Hong-Wei, Li, Xue-Qian, Zhao, Ming-Gang   +3 more
core   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source