Results 81 to 90 of about 14,929,096 (289)

Microbiome−host proteostasis crosstalk—An emerging perspective on mechanisms and interventions toward healthy longevity

FEBS Letters, EarlyView.
Proteostasis and the gut microbiota play a key role in shaping host physiology. Microbiota‐derived metabolites, vitamins, and RNA modulate host proteostasis. Findings from model systems, including C. elegans, indicate microbes can either stabilize or disrupt host proteostasis.
Abhishek Anil Dubey, Maria Ermolaeva
wiley   +1 more source

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

Hybrid adaptive Wolf-Particle swarm optimization algorithm and its application in CNN neural network hyperparameters optimization

Discover Computing
This paper introduces the Hybrid Adaptive Wolf-Particle Swarm Optimization (HAWPSO) algorithm, a novel metaheuristic framework designed to address the intricate challenge of optimizing hyperparameters in convolutional neural networks (CNNs) within ...
Keyin Chen, Jinzhen Xie
doaj   +1 more source

Structural insights and therapeutic targets in Acinetobacter baumannii capsule biosynthesis

FEBS Letters, EarlyView.
Hypervirulent KL49 A. baumannii's capsular polysaccharide contains the nonulosonic acid 8‐epi‐Leg5,7Ac2, synthesized by epimerization via ElaA, ElaB, and ElaC. Crystal structures of ElaA, ElaB, and ElaC reveal their role in CMP‐Leg5,7Ac2 synthesis and regioselective C8 epimerization.
Woo Cheol Lee, Junho Jeong, Chae Yeong Lee, Hyunjoon Cho, Man Hwan Oh, Je Chul Lee, Jee‐Young Lee, Yangmee Kim   +7 more
wiley   +1 more source

Data analysis evidence beyond correlation of a possible causal impact of weather on the COVID-19 spread, mediated by human mobility

Scientific Reports
Previous correlative and modeling approaches indicate influences of environmental factors on COVID-19 spread through atmospheric conditions’ impact on virus survival and transmission or host susceptibility.
Denis-Răducu Nichita, Mihai Dima, Loredana Boboc, Marian-Gabriel Hâncean   +3 more
doaj   +1 more source

Modelling stem cell differentiation related processes—A practical overview for biologists

FEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar, Xinqi Yan, Lucas F. Jansen Klomp, Stefano Schivo, Janine N. Post   +4 more
wiley   +1 more source

UNDERSTANDING SOLAR RADIATION: PHYSICS PRINCIPLES AT WORK

Worldwide Journal of Physics
Solar radiation is a fundamental aspect of renewable energy and plays a pivotal role in various natural and technological processes. This paper aims to elucidate the physics principles underlying solar radiation, exploring concepts such as the solar ...
Ahsan Zeb, Arif Mumtaz, Muhammad Nouman Sarwar Qureshi   +2 more
doaj  

“If I had to do it, then I would”: Understanding early middle school students’ perceptions of physics and physics-related careers by gender

Physical Review Physics Education Research, 2016
[This paper is part of the Focused Collection on Gender in Physics.] This study examined the perceptions of 6th grade middle school students regarding physics and physics-related careers.
Emily A. Dare, Gillian H. Roehrig
doaj   +1 more source

Design and analysis strategies for robust microbiome ageing research

FEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik, İsmail Güderer, Yi Wang, Tayyaba Alvi, Prasoon Pandey, Handan Melike Dönertaş   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source