Results 211 to 220 of about 267,978 (296)

Early clinical pharmacology evaluation of the novel anti‐inflammatory macrolide, glasmacinal (EP395): tolerability, pharmacokinetics and drug interactions

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aims This work assessed the pharmacokinetics (PK), safety and tolerability of glasmacinal (EP395, an oral anti‐inflammatory macrolide with negligible antimicrobial activity in development for COPD treatment) in two healthy participant trials: ‘first‐in‐human’ (FIH) and ‘drug–drug‐interaction’ (DDI).
Dave Singh, Kate Hanrott, Olof Breuer, Johan Bylund, Björn Schultze, Virginia Norris   +5 more
wiley   +1 more source

Challenges of after-hours pediatric imaging. [PDF]

Pediatr Radiol
Aquino MR, Shah J, Kaplan SL.
europepmc   +1 more source

A phase 1 evaluation of inhaled oxytocin: Physiologically‐based pharmacokinetic model informed dosing of a novel heat‐stable oxytocin delivery system

British Journal of Clinical Pharmacology, EarlyView.
Aim To develop and validate a physiologically‐based pharmacokinetic (PBPK) model enabling inhaled oxytocin dose selection for clinical evaluation. Subsequently, to conduct a phase 1 study investigating the pharmacokinetics and safety of selected doses of an optimized inhaled oxytocin product in healthy, non‐pregnant female participants.
Pete Lambert, Carl M. J. Kirkpatrick, Rory Marriott, Siladitya Ray Chaudhuri, David Polidori, Bart Remmerie, Michelle P. McIntosh   +6 more
wiley   +1 more source

Antioxidants and Exercise: A Redox-Informed Framework for Training Adaptation, Performance, and Recovery. [PDF]

Antioxidants (Basel)
Mănescu DC, Tudor A, Mănescu AM, Mărgărit IR, Mănescu CO, Prisăcaru C, Păun L, Tudor V.   +7 more
europepmc   +1 more source

From anthelmintic to neuro‐oncology: A systematic review of mebendazole repurposing for brain tumour therapy

British Journal of Clinical Pharmacology, EarlyView.
Abstract Aim Mebendazole (MBZ), a benzimidazole anthelmintic with established clinical use, has emerged as a repurposing candidate for primary brain tumours due to its multimodal anticancer actions and central nervous system penetrance. This systematic review synthesizes preclinical and clinical evidence evaluating MBZ's efficacy, mechanisms of action ...
Ciara B. Blum, Milli McMenamin, Tessa Khoo, John M. Edwin, Prathibha Jose, Liam A. O’Callaghan   +5 more
wiley   +1 more source

Troriluzole attenuates opioid intake, reinforcing efficacy, seeking behaviours, physical dependence and antinociceptive tolerance in rats. [PDF]

Br J Pharmacol
Galaj E, Inan S, Bi GH, Wiah S, Adamson G, Reitz AB, Xi ZX, Rawls SM.   +7 more
europepmc   +1 more source

Exploring new avenues: Psychedelic‐assisted therapy for young people

British Journal of Clinical Pharmacology, EarlyView.
Rates of mental illness in young people are increasing, whereas the development of novel mental health treatments has not significantly progressed. Psychedelic‐assisted therapy, using substances such as psilocybin and 3,4‐methylenedioxymethamphetamine (MDMA), has shown potential in the treatment of mental illnesses in the adult population, including ...
Ioanna Artemis Vamvakopoulou, Dasha Nicholls, David J. Nutt, Martina Di Simplicio   +3 more
wiley   +1 more source

The future in a bubble: Supporting Finnish early childhood professionals working in diverse settings

British Educational Research Journal, EarlyView.
Abstract The purpose of this study was to contribute to the knowledge about early childhood education and care (ECEC) personnel's perception of the support structures that are most effective in assisting them in their work with culturally and linguistically diverse children.
Alexandra C. Anton, Juli‐Anna Aerila, Elizabeth A. Steed   +2 more
wiley   +1 more source

A Glycopeptide Mosaic Vaccine Elicits Robust Antitumor Immunity by Targeting Glycan Heterogeneity. [PDF]

JACS Au
Wu Y, Ma W, Jiang Y, Ling Y, Zhou Y, Guo Y, Hong S, Ding F, Zhang J, Li B, Liang H, Wang Z, Li Y, Li T, Cai H.   +14 more
europepmc   +1 more source