Results 161 to 170 of about 23,609,372 (344)
Arbor: Ciencia, Pensamiento y Cultura, 2008 This paper has the purpose of showing the identity between science and technology from within scientific language. The traditional philosophical argument in favour of this identity is briefly examined, through the work of Heidegger. Then, following Henri Atlan (“Ordres et Significations”, 1979. Le crystal et la fumée. Essai sur l’organisation du vivant.
openaire +1 more source
ATF4‐mediated stress response as a therapeutic vulnerability in chordoma
Molecular Oncology, EarlyView.We screened 5 chordoma cell lines against 100+ inhibitors of epigenetic and metabolic pathways and kinases and identified halofuginone, a tRNA synthetase inhibitor. Mechanistically halofuginone induces an integrated stress response, with eIF2alpha phosphorylation, activation of ATF4 and its target genes CHOP, ASNS, INHBE leading to cell death ...
Lucia Cottone +11 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source
Health in Emergencies & Disasters Quarterly, 2017 Background: Experience of difficult incidents, besides its negative and adverse consequences, can have positive consequences and lead to the growth of people in several areas.
Mustafa Mardani +3 more
doaj
LDAcoop: Integrating non‐linear population dynamics into the analysis of clonogenic growth in vitro
Molecular Oncology, EarlyView.Limiting dilution assays (LDAs) quantify clonogenic growth by seeding serial dilutions of cells and scoring wells for colony formation. The fraction of negative wells is plotted against cells seeded and analyzed using the non‐linear modeling of LDAcoop.
Nikko Brix +13 more
wiley +1 more source
Journal of Rehabilitation, 2017 Objective Disability is a general concept that relate to a person's deprivations resulting from defects (disorder) disability. In other words, any lack or reduction in equal level of opportunity to participate in social life is called disability.
Paria Pourhossein Hendabad +3 more
doaj
Plecstatin inhibits hepatocellular carcinoma tumorigenesis and invasion through cytolinker plectin
Molecular Oncology, EarlyView.The ruthenium‐based metallodrug plecstatin exerts its anticancer effect in hepatocellular carcinoma (HCC) primarily through selective targeting of plectin. By disrupting plectin‐mediated cytoskeletal organization, plecstatin inhibits anchorage‐dependent growth, cell polarization, and tumor cell dissemination.
Zuzana Outla +10 more
wiley +1 more source
Robert Aumann and Thomas Schelling: Conflict and cooperation through the lens of game theory [PDF]
The Prize in Economic Sciences 2005: supplementary information to press release. Robert Aumann and Thomas Schelling have contributed to enhancing our understanding of conflict and cooperation. They have achieved this by extending and applying game theory
Committee, Nobel Prize
core
Molecular Oncology, EarlyView.Nanosecond infrared laser (NIRL) low‐volume sampling combined with shotgun lipidomics uncovers distinct lipidome alterations in oropharyngeal squamous cell carcinoma (OPSCC) of the palatine tonsil. Several lipid species consistently differentiate tumor from healthy tissue, highlighting their potential as diagnostic markers.
Leonard Kerkhoff +11 more
wiley +1 more source
Stephen Hawking (1942-2018), Towards a Complete Understanding of the Universe
, 2018 Two of the major achievements of Stephen Hawking are described in elementary terms. They are his work on the beginning of the universe and his work on the end of black holes. These are perhaps the scientific achievements for which he is best known.
Hartle, James
core