Results 251 to 260 of about 5,728,263 (355)

Proteasomal degradation of intracellularly expressed Amblyomin‐X limits suicide gene therapy potential in melanoma cells

FEBS Open Bio, EarlyView.
This study explores the feasibility of expressing the antitumoral protein Amblyomin‐X through a suicide gene therapy approach and investigates its intracellular fate after gene delivery. Although the gene is efficiently expressed, melanoma cells rapidly degrade the Amblyomin‐X protein via proteasome activity.
Victor Dal Posolo Cinel, Carlos DeOcesano Pereira, Aline Ramos Maia Lobba, Melissa Regina Fessel, Ana Marisa Chudzinski‐Tavassi   +4 more
wiley   +1 more source

Impact of team presenteeism atmosphere on presenteeism among ICU nurses: mediating effects of work stress and moderating effects of mindfulness. [PDF]

BMC Nurs
Li X, Wang X, Zhang C, Zhou J, Li T, Yang R.   +5 more
europepmc   +1 more source

MiR‐513a promotes human erythroid differentiation by modulating c‐Jun

FEBS Open Bio, EarlyView.
During early human erythropoiesis, miR‐513a promoted erythroid differentiation in primary human CD34+ hematopoietic stem‐progenitor cells and human TF‐1 erythroleukemic cells by indirectly decreasing c‐Jun and phospho‐c‐Jun expression, which are associated with increased GATA1 expression.
MinJung Kim, Brittany Taylor, Shannon Bolten, Christian L. Eberly, Mahliya Abdurahman, T. Michael Creed, Acong Yang, Taylor L. Hatchet, Tristan Dyson, Shuo Gu, Curt I. Civin, Tami J. Kingsbury   +11 more
wiley   +1 more source

Digital twins to accelerate target identification and drug development for immune‐mediated disorders

FEBS Open Bio, EarlyView.
Digital twins integrate patient‐derived molecular and clinical data into personalised computational models that simulate disease mechanisms. They enable rapid identification and validation of therapeutic targets, prediction of drug responses, and prioritisation of candidate interventions.
Anna Niarakis, Philippe Moingeon
wiley   +1 more source

Association between work stress and sleep disturbances: the mediating role of pre-sleep arousal symptoms. [PDF]

Ind Health
Min J, Ryu H, Cho SS, Kang MY.
europepmc   +1 more source

The roots of work related stress : A qualitative study on perceived stress factors, their origin and impact on the psychosocial work environment of middle managers.

Isaksson, Therese, Sundström, Elina
openalex   +1 more source

The Art Therapy in Groups' on the work Stresses and Emotional Burnouts of Social Workers for Diabled Facility

, 2016
Misun Cha, Ji-Hyun Shin
openalex   +1 more source

Rapid screening of staphylokinase protein variants using an unpurified cell‐free expression system

FEBS Open Bio, EarlyView.
An unpurified cell‐free protein synthesis (CFPS) platform enables rapid functional screening of staphylokinase variants. Direct plasminogen‐activation assays performed in microplate format provide real‐time activity readouts, allowing rapid identification and ranking of variants with improved or reduced fibrinolytic activity without protein ...
Maria Tomková, Veronika Hovanová, Jiri Damborsky, Erik Sedlák   +3 more
wiley   +1 more source

Mediating role of emotional intelligence in the relationship between dual work stress and reflective ability among junior nurses. [PDF]

BMC Nurs
Zhang M, Wu J, Yang Y, Song J, Shen Q.
europepmc   +1 more source