Results 91 to 100 of about 21,450,254 (260)

Modelling stem cell differentiation related processes—A practical overview for biologists

open access: yesFEBS Letters, EarlyView.
Stem cell differentiation is complex and difficult to control experimentally. This review introduces suitable computational modelling approaches that can support stem cell research, from mechanistic ODE and abstract models to multiscale and deep learning methods.
Ricco Zeegelaar   +4 more
wiley   +1 more source

Determinants of Occupational Gender Segregation : Work Values and Gender (A)Typical Occupational Preferences of Adolescents [PDF]

open access: yes, 2011
Busch A. Determinants of Occupational Gender Segregation : Work Values and Gender (A)Typical Occupational Preferences of Adolescents. SFB 882 Working Paper Series. Vol 2. Bielefeld: DFG Research Center (SFB) 882 From Heterogeneities to Inequalities; 2011.
Busch, Anne
core  

(In)satisfação dos valores laborais e estresse: análise de um modelo moderacional (Dis)satisfaction of working values and stress: analysis of a moderational model

open access: yesPsicologia: Teoria e Pesquisa, 2013
O presente estudo objetivou testar um modelo empírico que investiga o poder moderacional da idade e do nível hierárquico sobre a relação entre a (in)satisfação dos valores do trabalho e o estresse psíquico.
Margareth Ribeiro M. S. Silva   +1 more
doaj  

Design and analysis strategies for robust microbiome ageing research

open access: yesFEBS Letters, EarlyView.
The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik   +5 more
wiley   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

The Value of Joint Working Parties

open access: yesWork, Employment and Society, 1996
It is argued that policy makers, in government especially, use crude output measures such as the link with performance to argue the case for, or more often against, employee participation. The paper considers the problems associated with the use of such crude output measures but argues that researchers cannot avoid the question of what impact ...
Kessler, I, Purcell, J
openaire   +2 more sources

Identification of a Shiga toxin A‐derived peptide internalized into Gb3 receptor‐bearing cells via interaction with the Shiga toxin B subunit

open access: yesFEBS Letters, EarlyView.
The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi   +6 more
wiley   +1 more source

Work Values in European Countries: Empirical Evidence and Explanations [PDF]

open access: yesRevista de Management Comparat International, 2011
This exploratory study mapped work values in European countries and examined socio-economic and cultural explanations of between-country differences in the relative importance of various work values.
Anneli KAASA
doaj  

Age, Period, and Cohort Differences in Work Centrality and Work Values

open access: yesSocieties, 2018
In this paper, we analyze whether work values differ between three dimensions of time (age, birth cohort, period). Using data of five waves of the World Values Survey and the European Values Study from more than forty countries and hierarchical age ...
Gábor Hajdu, Endre Sik
doaj   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

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