Results 41 to 50 of about 41,897 (308)

Phosphoinositides and inositol phosphates as molecular glues

FEBS Letters, EarlyView.
Inositol phosphates (IPs) and phosphoinositides (PIPs) regulate diverse eukaryotic processes. Beyond recruiting signaling proteins or acting as structural cofactors, recent studies suggest they mediate protein–protein interactions as natural molecular glues.
Aleshia Seaton‐Terry, Alexander J. Cutright, Mong Na Claire Loi, Jessica Martin, Joseph W. Gilligan, Jakub N. Kubina, Michael J. Arambula, Susanna Tanada Palmu, Daniella Zhou, Raymond D. Blind   +9 more
wiley   +1 more source

The impact of heat and impaired kidney function on productivity of Guatemalan sugarcane workers. [PDF]

PLoS ONE, 2018
BACKGROUND:Climate change has implications for human health and productivity. Models suggest that heat extremes affect worker health, reduce labor capacity, and commodity supply. Chronic health conditions are on the rise internationally. However there is
Miranda Dally, Jaime Butler-Dawson, Lyndsay Krisher, Andrew Monaghan, David Weitzenkamp, Cecilia Sorensen, Richard J Johnson, Elizabeth J Carlton, Claudia Asensio, Liliana Tenney, Lee S Newman   +10 more
doaj   +1 more source

Three phosphatase families form a community: The phosphohydrolases that act upon inositol pyrophosphates

FEBS Letters, EarlyView.
Inositol pyrophosphates are energy‐rich signaling molecules that perform critical functions in cells. Three different families of phosphatases hydrolyze the β phosphate of the inositol pyrophosphate molecules: two have narrow specificities and one is promiscuous.
Ronda J. Rolfes
wiley   +1 more source

Working Productivity Analysis on the Process of Drying Fish Using Solar Dryers

Logic, 2021
The process of drying fish using solar energy is strongly influenced by weather conditions. Sunlight is needed by household scale workers because it is cheap. On the other hand, sun drying creates additional workload for workers.
I Gede Santosa, I Gede Bawa Susana
doaj   +1 more source

Mixed‐class J‐domain protein scaffolds promote expanded aggregate handling and multivalent Hsp70 engagement during functional disaggregase assembly

FEBS Letters, EarlyView.
Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley   +1 more source

Knowledge management and performance: developing a theoretical approach to knowledge workers’ productivity, and practical tools for managers [PDF]

Problems and Perspectives in Management, 2016
Issue: The number of knowledge workers continues to grow, but we know little about what factors will promote knowledge workers’ productivity. Problem for discussion: How can managers promote knowledge workers’ productivity? Purpose: To develop aspects of
Deniel J. Adriaenssen, Dagny A. Johannessen, Jon-Arild Johannessen   +2 more
doaj   +1 more source

Worker Productivity in Operations Management

Foundations and Trends® in Technology, Information and Operations Management, 2019
From Frederick Taylor’s study of brick laying manual laborers in the early 20th century, to the multi-year benchmarking of automotive plant productivity as part of the International Motor Vehicle Program, the systematic observation, measurement, and analysis of work has a strong tradition in operations management. Traditional manufacturing provided the
openaire   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Beyond the Farm Gate: Drivers of Farm Labor Productivity in BRICS+ Agrifood Systems [PDF]

BIO Web of Conferences
Agriculture still employs large shares of the workforce in many BRICS and BRICS-aligned economies, yet output per worker remains uneven across countries.
Irawan Evi
doaj   +1 more source

Mass spectrometry based identification of AMP‐O‐Tris generated by Thermococcus onnurineus Cas10

FEBS Open Bio, EarlyView.
Isolated Thermococcus onnurineus Cas10 generates the noncanonical ATP‐derived product AMP‐O‐Tris while in Tris‐containing buffer as identified via mass spectrometry, revealing relaxed nucleophile selectivity under isolated conditions. These findings suggest that multiprotein Csm complex assembly restricts Cas10 reactivity toward canonical cyclic ...
Su‐Jin Lee, Ga Seul Lee, JinHan Kim, Kwang‐Hyun Park, Seong‐Ryung Go, Jeong Hee Moon, Eui‐Jeon Woo   +6 more
wiley   +1 more source