Results 71 to 80 of about 90,229 (257)
FEBS Letters, EarlyView.Although too much iron in the brain promotes neurodegeneration, iron ion chelators have had mixed effects in clinical trials. This review explains why; some chelators do not render the iron redox‐inactive (e.g., L1) whereas others do (e.g., desferrioxamine).
Barry Halliwell
wiley +1 more source
Modelling of Heat Fluxes from Surface of KRO-200 Container Using Adaptive Technologies
Energy Engineering and Control SystemsThis paper presents the results of modeling heat fluxes from the outer surface of the KRO-200 container. The study was conducted for a temperature range of 40–150 °C.
Tetiana Rymar +3 more
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Improving Worker Safety Through Better Visibility
Journal of Road Safety, 2010 Road trauma represents a significant cost on society, and governments are developing various measures and safety programs to reduce the number of fatal accidents and serious injuries.
Agota Berces
doaj
Molecular Oncology, EarlyView.We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric +10 more
wiley +1 more source
Applied Sciences, 2018 In the Korean construction industry, legal and institutional safety management improvements are continually being pursued. However, there was a 4.5% increase in the number of workers’ deaths at construction sites in 2017 compared to the previous ...
Sung Hun Kim +3 more
doaj +1 more source
Molecular Oncology, EarlyView.Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena +15 more
wiley +1 more source
A staffing perspective on barriers to and facilitators of temporary worker safety and health. [PDF]
Am J Ind Med, 2023 Menger-Ogle LM +3 more
europepmc +1 more source
Molecular Oncology, EarlyView.The novel styrylquinazolinone‐based molecule W1B effectively suppresses glioblastoma by inhibiting IGF1R and EGFR. In high‐glucose microenvironments driving tumor resistance, W1B acts synergistically with the EGFR inhibitor dacomitinib. This combination safely blocks compensatory survival signaling in zebrafish xenograft models. Showcasing promising in
Patryk Rurka +9 more
wiley +1 more source
Computer Vision-Based Safety Monitoring of Mobile Scaffolding Integrating Depth Sensors
BuildingsMobile scaffolding is essential in construction but presents significant safety risks, particularly falls from height (FFH) due to improper use and insufficient monitoring.
Muhammad Sibtain Abbas +4 more
doaj +1 more source