Results 91 to 100 of about 7,008,070 (297)
An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes
FEBS Letters, EarlyView.GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg +14 more
wiley +1 more source
Le vote ouvrier et l’élection de Donald Trump : histoire et limites du discours populiste
Revue LISA, 2018 This article examines the voting behavior of the white working class in the deindustrialized regions of the Northeast and Midwest in 2016. Although recent evolutions in American politics may account for the pro-Trump vote in the Rust Belt states, this ...
Tamara Boussac
doaj +1 more source
Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
Counting the Working Class for WorkingClass Studies: Comparing Three OccupationBased Definitions
, 2019 A wide variety of definitions of the working class are in use across disciplines and even within working-class studies (Cohen 2001; Zweig 2001; Metzgar 2003; Wilson 2016; Wilson and Roscigno 2018). Responding to Zweig’s (2016) call to maintain continuity
King, Colby
core +1 more source
Conscience politique et conscience photographique
Images du Travail, Travail des Images, 2016 After many years spent sorting and indexing photographs from labour union archives, Xavier Nerrière aims at bringing out the interest of the concept of self-representation, in the scientific as well as in the patrimonial field.
Xavier Nerrière
doaj +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation
FEBS Letters, EarlyView.Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang +2 more
wiley +1 more source
Liver organoids: modelling complexity in homeostasis and disease
FEBS Letters, EarlyView.Studying liver in vitro has been challenging because simple 2D cell cultures fail to capture liver's cellular and architectural complexity. To bridge this gap, scientists increasingly use organoids, 3D liver models which better mimic liver composition and function. This review examines recent advances in liver organoid complexity and realism, discusses
Anna M. Dowbaj, Meritxell Huch
wiley +1 more source
The Moral Economy of Department Stores’ Working-Class and their Class Identity
, 2018 Globalised capitalism has changed the landscape of the working-class in different ways both in the Global North and in the Global South, including identities, moral frames, working places, and livelihood strategies.
Marambio-Tapia, Alejandro
core +1 more source