Structure‐forward targeting of claudins with synthetic binders
FEBS Letters, EarlyView.Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley +1 more source
"I'm a bit middle class, a bit working class, a bit white and a bit Caribbean" - the retention of nurses in general practice and the intersection of professional and societal level cultural and structural issues: a qualitative interview study. [PDF]
BMC Health Serv ResAnderson H, Brady L, Adamson J.
europepmc +1 more source
Everyday tactics in local moral worlds: E-cigarette practices in a working-class area of the UK. [PDF]
Soc Sci Med, 2016 Thirlway F.
europepmc +1 more source
FEBS Letters, EarlyView.Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas +4 more
wiley +1 more source
Affordable 3D Orientation Visualization Solution for Working Class Remotely Operated Vehicles (ROV). [PDF]
Sensors (Basel)Kasno MA, Yahaya IN, Jung JW.
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LS Lowry, the condition of the working class and the birth of the NHS. [PDF]
London J Prim Care (Abingdon), 2014 Carelli F.
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Peripheral lysosomes recruit PLEKHG3 to focal adhesions and restrain protrusion dynamics
FEBS Letters, EarlyView.Proximity‐dependent labeling at the LAMTOR complex revealed the Rho GEF PLEKHG3 as a lysosome‐proximal protein directing the study toward the influence of lysosome positioning on actin dynamics and cell motility. We show that PLEKHG3 colocalizes with lysosomes at focal adhesion sites and observe that forced peripheral dispersion of lysosomes hinders ...
Rainer Ettelt +8 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Parenting Stress among Low-Income and Working-Class Fathers: The Role of Employment. [PDF]
J Fam Issues, 2016 Nomaguchi K, Johnson W.
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