Results 131 to 140 of about 432,742 (265)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

FEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens, Brendan W. Chandler, Anna M. Schmoker, Jaye L. Weinert, Charlotte A. Kearns, Warren T. Yacawych, Amila Šemić, Alicia M. Ebert, Bryan A. Ballif   +8 more
wiley   +1 more source

Knowledge and Attitude of Working-Class Women Towards Exclusive Breastfeeding in Kwara State, Nigeria: Implications for Counselling Practice. [PDF]

Ethiop J Health Sci
Adegboyega LO, Okafor IP, Okesina FA, Ajiboye SK, Bello MB.   +4 more
europepmc   +1 more source

Reconstructing enzyme evolution by protein engineering

FEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler, Markus R. Busch, Reinhard Sterner   +2 more
wiley   +1 more source

Preschool teachers provide fewer participation opportunities to working-class students than those from more privileged backgrounds. [PDF]

Proc Natl Acad Sci U S A
Doyle L, Cimpian A, Goupil L, Goudeau S.
europepmc   +1 more source

Nicotine addiction as a moral problem: Barriers to e-cigarette use for smoking cessation in two working-class areas in Northern England. [PDF]

Soc Sci Med, 2019
Thirlway F.
europepmc   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

FEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta, Hari Baskar Balasubramanian, Amir Pasokh, Marietta Zille   +3 more
wiley   +1 more source

Class, gender and the work of working-class women amid turbulent times. [PDF]

Br J Sociol
Warren T, Torres L, Lyonette C, Tarlo R.
europepmc   +1 more source

Workplace Policies and Mental Health among Working-Class, New Parents. [PDF]

Community Work Fam, 2017
Perry-Jenkins M, Smith JZ, Wadsworth LP, Halpern HP.   +3 more
europepmc   +1 more source

An epithelial GPR35 isoform supports tumor‐associated transcriptional and metabolic phenotypes

FEBS Letters, EarlyView.
GPR35 generates two functionally distinct isoforms with previously unresolved roles. GPR35‐short mediates immune‐cell chemotaxis, while GPR35‐long is enriched in colorectal cancer epithelium, where it supports increased metabolism, proliferation, and tumor‐associated transcriptional programs.
Jørgen D. Rønneberg, Martine Hjeltnes, Josephine Krieger, Joshua E. Elias, Maria Stensland, Kristian Holm, Xiaojun Jiang, Chuki Khangsar, Tuula A. Nyman, Arthur Kaser, Johannes R. Hov, Tom H. Karlsen, Nicole C. Kaneider, Frode L. Jahnsen, Georg Schneditz   +14 more
wiley   +1 more source

A full-spectrum aqueous extract of black cardamom (<i>Amomum subulatum</i>) improves focus/alertness and executive function: a randomized, double-blinded, placebo- and active-controlled, comparative study in healthy working-class participants. [PDF]

Front Neurosci
Thomas JV, Mohan ME, Das SS, Allimuthu N, Devasia S, Aneesa PA, Madhavamenon KI, Sasidharan BCP.   +7 more
europepmc   +1 more source