Results 81 to 90 of about 8,357,911 (282)

ABL kinase‐dependent phosphorylation of SH proteins promotes their direct interaction with CRK family SH2 domains

open access: yesFEBS Letters, EarlyView.
CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens   +8 more
wiley   +1 more source

Pumping machine working condition type number table.

open access: yes, 2023
Pumping machine working condition type number table.
Zejun Yao (17041356)   +5 more
core   +1 more source

Detection and Diagnosis of Rolling Element Bearing Faults Using Time Encoded Signal Processing and Recognition [PDF]

open access: yes
This thesis presents a systematic study of using TESPAR (Time Encoded Signal Processing and Recognition), which presently is in use as an effective tool for speech recognition and shows great advantages in computational demands and accuracy, to develop a
Abdusslam, Shukri Ali
core   +1 more source

Case Report: Frontalis sign for early bedside consideration of impending uncal herniation [version 2; referees: 2 approved]

open access: yesF1000Research, 2016
It is prudent to have early diagnosis and timely management of uncal herniation for better management of neurosurgical patients. There are several clinical and radiological armamentariums that aid in early recognition of the condition.
Sunil Munakomi, Bijoy Mohan Kumar
doaj   +1 more source

Reconstructing enzyme evolution by protein engineering

open access: yesFEBS Letters, EarlyView.
Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler   +2 more
wiley   +1 more source

Investigating transcription factor dynamics in health and disease using FRAP

open access: yesFEBS Letters, EarlyView.
FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj   +3 more
wiley   +1 more source

Microbiome‐blood–brain barrier interactions in aging — mechanisms and therapeutic potential

open access: yesFEBS Letters, EarlyView.
Aging reshapes the gut microbiome (↓SCFA‐producing commensals; ↑pro‐inflammatory outputs), shifting circulating metabolites (↓SCFAs; ↑LPS, ↑TMAO, ↑PAA) that act at the BBB to increase nonspecific transcytosis, alter transport, and promote astrocyte reactivity, heightening brain vulnerability.
Daniel Cuervo‐Zanatta   +3 more
wiley   +1 more source

Differential effects of working memory load on priming and recognition of real images

open access: yes, 2020
Several studies have explored the effects of divided attention on priming, but little is known about the impact of working memory load on implicit visual memory.
Castellà, J   +3 more
core   +1 more source

Impact of motor error processing on performance on a working memory task: effect of modulating cognitive load in high and low span groups

open access: yesActa Psychologica
Making a motor error, hitting the wrong key for example in responding to a stimulus, impacts perceptual, motor, and cognitive processes by implying a variation in performance and response time on the next trial (Post Error Slowing, Dutilh et al., 2012 ...
Emilien Brochet   +2 more
doaj   +1 more source

A team without a name: emergency medicine recognition and its impact on working conditions and well-being

open access: yesMedizinische Klinik - Intensivmedizin und Notfallmedizin
Abstract Emergency medicine (EM) has evolved significantly over the past 50 years, transitioning from a focus on acute injuries and illnesses to include primary and specialty care, disaster response, and social issues. To date, nearly 60 countries have officially recognized EM as a medical specialty.
Megan Gates Kemnitz   +6 more
openaire   +4 more sources

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