Results 91 to 100 of about 8,357,911 (282)

Structure‐forward targeting of claudins with synthetic binders

FEBS Letters, EarlyView.
Claudins form the paracellular barriers between epithelial and endothelial tissues at tight junctions and are targets for molecular binders with the goal of modulating barrier permeability. Claudin‐binding molecules are relevant in drug delivery or in altering claudin interactions with disease‐causing proteins.
Alex J. Vecchio
wiley   +1 more source

Nutrient/TOR signaling controls adipose mitochondrial transcription factor A (TFAM) to regulate organismal growth in Drosophila

FEBS Letters, EarlyView.
Animals must match their growth rate to available nutrients. We show that in Drosophila larvae, the nutrient‐sensing TOR kinase controls growth by regulating levels of TFAM, a key regulator of mitochondrial function, in the adipose tissue. When nutrients are abundant, high TOR activity suppresses TFAM, lowering mitochondrial bioenergetic activity and ...
Shrivani Sriskanthadevan‐Pirahas, Shahoon Khan, Abhishek Sharma, Byoungchun Lee, Savraj S. Grewal   +4 more
wiley   +1 more source

Nonlinear Model Predictive Control Energy Management Strategy for Hybrid Power Ships Based on Working Condition Identification

Journal of Marine Science and Engineering
Hybrid power technology for ships is an effective way to promote the green and low-carbon development of the maritime industry. The development of pattern recognition technology provides new research ideas for the rational allocation and utilization of ...
Yucheng Yan, Zhichao Chen, Diju Gao
doaj   +1 more source

Factors Associated to Basic Emergency Obstetric Neonatal Care (BEONC) Nurses' Decision Making Skill

Jurnal Keperawatan Soedirman, 2018
Neonatal mortality rate (NMR) is an indicator to measure health degree of an area, health problem which involves some institutions to take a decision.
Ahsan Ahsan, Ni Luh Diah Ayu Sita Dewi, Ali Haedar, Ike Nesdia Rahmawati   +3 more
doaj   +1 more source

Engineering peptides into antibodies—opportunities and strategies for therapeutic innovation

FEBS Letters, EarlyView.
Peptides and antibodies occupy complementary therapeutic niches. Peptides recognize difficult targets in a compact format, while antibodies add specificity, long half‐life, and effector functions. This review examines strategies that merge both modalities—peptide grafting into loops, terminal and Fc fusions, and bioconjugation—highlighting how ...
Jinling Wang, Ruslana Romaniuk, Hristo L. Svilenov   +2 more
wiley   +1 more source

On including quality in applied automatic gait recognition

, 2012
Many gait recognition approaches use silhouette data. Imperfections in silhouette extraction have a negative effect on the performance of a gait recognition system.
Matovski, D., Mahmoodi, S., Nixon, M., Mansfield, T.   +3 more
core   +1 more source

Partial depletion of plasminogen activator inhibitor‐1 decreases subcutaneous fat cell hypertrophy and liver cholesterol in high‐fat‐fed female mice

FEBS Letters, EarlyView.
Obesity raises blood levels of PAI‐1, a protein linked to metabolic dysfunction‐associated steatotic liver disease in people with obesity. In female mice fed a high‐fat diet, partially lowering PAI‐1 led to smaller subcutaneous fat cells and lower liver cholesterol, without changing body weight or insulin sensitivity.
Claudia E. Ramirez Bustamante, Robert Sharp, Pradip K. Saha, Elizabeth S. Anaya, Elizabeth L. Lieu, Evelyn L. de Groot, Pooja Patel, Mi Jeong Heo, Aaron R. Cox, Kang Ho Kim, Sean M. Hartig   +10 more
wiley   +1 more source

Research of the Operational Modal Parameter Identification Technology and Application based on QICA

Jixie chuandong, 2015
Aiming at the major difficulties of OMA method based on vibration signals such as low noise-robust ability,high subjective experience and poor accuracy in identifying parameters and more complex recognition method,a new method of OMA on the basis of QICA
Zhang Rui, He Changde, Huang Jinying, Zhang Yongmei, Xue Chenyang, Zhang Wendong   +5 more
doaj  

Emerging experimental and computational methods for studying redox‐regulated structural transitions

FEBS Letters, EarlyView.
Redox reactions can reshape proteins and alter how they behave in cells, with important consequences for health and disease. This review explores emerging experimental and computational approaches for discovering these redox‐sensitive protein switches, revealing their structural effects, and predicting their behavior, opening new opportunities to ...
Tasneem Rass, Dana Reichmann, Gábor Erdős   +2 more
wiley   +1 more source

Research on Oil and Gas Pipeline Leakage Detection Based on MSCNN-Transformer

Applied Sciences
The leakage detection of oil and gas is very important for the safe operation of pipelines. The existing working condition recognition methods have limitations in processing and capturing complex multi-category leakage signal characteristics. In order to
Yingtao Zhang, Wenhe Li, Yang Wu, Huili Wei   +3 more
doaj   +1 more source