Disordered but rhythmic—the role of intrinsic protein disorder in eukaryotic circadian timing
FEBS Letters, EarlyView.Unstructured domains known as intrinsically disordered regions (IDRs) are present in nearly every part of the eukaryotic core circadian oscillator. IDRs enable many diverse inter‐ and intramolecular interactions that support clock function. IDR conformations are highly tunable by post‐translational modifications and environmental conditions, which ...
Emery T. Usher, Jacqueline F. Pelham
wiley +1 more source
THE AGEING WORKFORCE IN IRELAND: WORKING CONDITIONS, HEALTH AND EXTENDING WORKING LIVES. ESRI RESEARCH SERIES NUMBER 92 OCTOBER 2019 [PDF]
, 2019 Extending working lives is a central element of active ageing policy in Ireland and Europe, and is seen as promoting active lifestyles and sustaining social protection systems in the context of an ageing population.
Maitre, Bertrand +2 more
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Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation
FEBS Letters, EarlyView.Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe +3 more
wiley +1 more source
Employees’ Self-Realization in Different Working Conditions
, 2023 Guzel R. Baimurzina, Elena V. Kabashova
openalex +1 more source
Integration of circadian and hypoxia signaling via non‐canonical heterodimerization
FEBS Letters, EarlyView.CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley +1 more source
Can Better Working Conditions Improve the Performance of SMEs? An International Literature Review [PDF]
, 2013 [Excerpt] It is widely recognized that competitive private enterprise is the principal source of economic growth and wealth globally and makes a substantial contribution to poverty reduction.
Croucher, Richard +3 more
core +1 more source
Function‐driven design of a surrogate interleukin‐2 receptor ligand
FEBS Letters, EarlyView.Interleukin (IL)‐2 signaling can be achieved and precisely fine‐tuned through the affinity, distance, and orientation of the heterodimeric receptors with their ligands. We designed a biased IL‐2 surrogate ligand that selectively promotes effector T and natural killer cell activation and differentiation. Interleukin (IL) receptors play a pivotal role in
Ziwei Tang +9 more
wiley +1 more source
Judicial perceptions on working time
SortuzJudicial systems across different jurisdictions and regions of the world have, in recent years, been subject to judicial reforms that have reconfigured the way judges work.
Madalena Cid Teles, Paula Casaleiro
doaj +1 more source
Psychophysiological expertise as a key chain in occupational selection and monitoring of professionally important qualities in specialists, working in conditions of high danger [PDF]
, 2013 V. V. Kalnysh
openalex +1 more source
Working Conditions, Absence and Gender - a Multilevel Study [PDF]
In this paper we use data that combines employment records with employee survey responses to study to what extent psychosocial working conditions, measured at the work group level, relate to individual short-term and long-term sick leave.
Bokenblom, Mattias, Ekblad, Kristin
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