Results 141 to 150 of about 13,029,186 (274)

Circular RNA expression landscapes in myelodysplastic neoplasms: Associations with mutational signatures and disease progression

open access: yesMolecular Oncology, EarlyView.
In this explorative study, the abundance of circular RNA molecules in bone marrow stem cells was found to be elevated in patients with high‐risk myelodysplastic neoplasms, and to be associated with an increased risk of progression to acute myeloid leukemia.
Eileen Wedge   +17 more
wiley   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

open access: yesMolecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla   +9 more
wiley   +1 more source

Condições de trabalho e saúde mental dos médicos de Salvador, Bahia, Brasil

open access: yesCadernos de Saúde Pública
Um estudo de corte transversal investigou a associação entre as condições de trabalho e distúrbios psíquicos menores (DPM) em uma amostra aleatória de 350 médicos de Salvador, Bahia, Brasil.
Carlito Lopes Nascimento Sobrinho   +4 more
doaj  

Survey on the Working Conditions, Salary, and Job Satisfaction of Employed Veterinarians in Germany. [PDF]

open access: yesVet Sci
Jensen KC   +5 more
europepmc   +1 more source

Differential expression of cancer‐related genes supports prediction of poor response to first‐line treatments in T‐ALL pediatric patients with high minimal residual disease

open access: yesMolecular Oncology, EarlyView.
In the present work, we have identified a transcriptional signature based on the differential expression of six genes (BCL2&MAST4, HSH2D&LAT2, METRN&PITPNM2) that would facilitate the early detection of T‐cell acute lymphoblastic leukemia (T‐ALL) patients prone to a poor treatment response and could be implemented at diagnosis, along with other risk ...
Antonio Lahera   +11 more
wiley   +1 more source

Adaptation and validation of safety attitudes questionnaire (SAQ-SF ) for use in Poland

open access: yesProblemy Pielęgniarstwa
Łukasz Lompart   +2 more
doaj   +1 more source

Condições de trabalho e saúde dos professores da rede particular de ensino de Vitória da Conquista, Bahia, Brasil

open access: yesCadernos de Saúde Pública
A literatura científica sobre a saúde dos professores é escassa e recente, enfocando especialmente o desgaste e estresse. Este trabalho objetivou descrever as condições de trabalho e saúde dos professores da rede particular de ensino da cidade de Vitória
Núria Serre Delcor   +7 more
doaj  

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