Results 201 to 210 of about 15,854,076 (410)
Loss of proton‐sensing GPR4 reduces tumor progression in mouse models of colon cancer
G protein‐coupled receptor 4 (GPR4) is a pH‐sensing receptor activated by acidic pH. GPR4 expression is increased in patients with inflammatory bowel disease who are at high risk of developing colorectal cancer. In mouse models, loss of GPR4 attenuated tumor progression. This correlated with increased IL2 and natural killer cell activity.
Leonie Perren+16 more
wiley +1 more source
TRPM8 levels determine tumor vulnerability to channel agonists
TRPM8 is a Ca2+ permissive channel. Regardless of the amount of its transcript, high levels of TRPM8 protein mark different tumors, including prostate, breast, colorectal, and lung carcinomas. Targeting TRPM8 with channel agonists stimulates inward calcium currents followed by emptying of cytosolic Ca2+ stores in cancer cells.
Alessandro Alaimo+18 more
wiley +1 more source
Working conditions in Russia [PDF]
Amina Nazaralieva, Clare Oakley
openaire +2 more sources
Working Conditions in Complementary and Integrative Healthcare Professions. [PDF]
Whitley MD+3 more
europepmc +1 more source
A Model to Analyze Ergonomics Working Conditions [PDF]
Bahador Ghahramani
openalex +1 more source
Quality of Life and Working Conditions of Plastic Surgeons and Trainees: A National Survey. [PDF]
Dietrich LG+3 more
europepmc +1 more source
The pan‐HDAC inhibitor belinostat increases the expression of the pro‐apoptotic proteins Bim, Puma, and Noxa and induces apoptosis in ovarian cancer cell lines and patient‐derived tumor organoids when used at high concentrations. Moreover, inhibiting the anti‐apoptotic proteins Bcl‐xL or Mcl‐1 sensitizes these preclinical models to the cytotoxic effect
Cécilia Thomine+10 more
wiley +1 more source
Occupational hazard of female film rolling workers and effects of improved working conditions
openalex +2 more sources