Results 121 to 130 of about 4,676,319 (282)

Threonine 348 regulates the subcellular localization of PTEN

FEBS Open Bio, EarlyView.
Thr348 in the C2 domain is a key contributor to PTEN subcellular localization. The PTEN350 fragment and PTENA4 accumulated in the nucleus, whereas PTENK13R,A4 predominantly localized to the plasma membrane. In contrast, substitution of Thr348 with Asp (T348D) disrupted these characteristic localization patterns, resulting in predominant cytoplasmic ...
Takashi Kato, Suzu Tanaka, Miyu Ohashi
wiley   +1 more source

Cell surface CD11c as a neutrophil aging marker molecule

FEBS Open Bio, EarlyView.
Cell surface CD11chi neutrophils were more aged and had better phagocytic function than CD11c−/lo neutrophils. Transcriptomic analysis of CD11chi neutrophils and CD11c−/lo neutrophils in pediatric population showed that the most difference was seen in infants.
Sophia Koutsogiannaki, Fahd Alhamdan, Erik Malm, Marie Bermudez, Samuel Y. Kim, Koichi Yuki   +5 more
wiley   +1 more source

Dynamics of salivary cortisol and oxytocin during standardized field training in search-and-rescue (SAR) dogs

Frontiers in Veterinary Science
Search and rescue (SAR) dogs perform physically and cognitively demanding tasks under complex field conditions. The aim of this study was to characterize temporal changes in salivary cortisol and oxytocin concentrations during standardized simulated SAR ...
Petra Bolechová, Eva Chmelíková, Adéla Polónyiová, Hana Vostrá-Vydrová, Adéla Dokoupilová, Ivona Svobodová   +5 more
doaj   +1 more source

Evaluation of PCR as a diagnostic mass-screening tool to detect Leishmania (Viannia) spp. in domestic dogs (Canis familiaris)

, 2003
Several studies have suggested that the PCR could be used in epidemiological mass-screening surveys to detect Leishmania (Piannia) spp. infection in human and animal hosts.
Reithinger, Richard, Courtenay, Orin, Espinoza, Juan Canales, J. C. Espinoza, R. Reithinger, C. R. Davies, O. Courtenay, Davies, Clive R   +7 more
core   +1 more source

BCG vaccination potentiates oxidative phosphorylation in neonatal myeloid‐derived suppressor cells

FEBS Open Bio, EarlyView.
BCG vaccination enhances oxidative phosphorylation in neonatal MDSCs, impairing their immunosuppressive function. It upregulates electron transport chain genes and mitochondrial activity, increasing ATP and oxygen consumption. Pharmacological OXPHOS inhibition partially restores suppressive capacity, confirming causality.
Yingying Chen, Hui Li
wiley   +1 more source

Editorial: Our Canine Connection: The History, Benefits and Future of Human-Dog Interactions

Frontiers in Veterinary Science, 2021
Eric G. Strauss, Sandra McCune, Sandra McCune, Evan MacLean, Evan MacLean, Evan MacLean, Evan MacLean, Aubrey Fine   +7 more
doaj   +1 more source

The C‐terminal truncated splicing variant of NK1R negatively modulates substance P‐stimulated NK1R signaling

FEBS Open Bio, EarlyView.
The neurokinin 1 receptor exists as full‐length (NK1L) and C‐terminally truncated (NK1S) splice variants. We show that NK1S heterodimerizes with NK1L, impairing Gαq coupling and Ca2+ mobilization while enhancing β‐arrestin1 recruitment. NK1S suppresses substance P‐driven gene expression and cell migration, revealing NK1S as an endogenous biased ...
Lan Phuong Nguyen, Duc Trung Nguyen, Minyoung Cho, Jihun Kim, Soyeon In, Thai Uy Nguyen, Sunghoon Hurh, Beom Jin Park, Jong‐Ik Hwang   +8 more
wiley   +1 more source

Understanding the roles of dogs in conservation & wildlife conflict mitigation

The use of dogs in wildlife management remains a controversial topic across the United States and globally. Dogs may be used in a number of wildlife management contexts including hunting, predator deterrence, and conservation detection (USDA, 2017 ...
Williams, Bailey C.
core   +4 more sources

MARK4 enhances stress granule formation under oxidative stress and increases tau accumulation

FEBS Open Bio, EarlyView.
MARK4 (red dots) localizes to stress granules (orange dots) and promotes their formation under oxidative stress by modulating TIA1 (blue dots). MARK4 and TIA1 synergistically increase tau (purple) accumulation, and the reduction of the TIA1 ortholog suppresses neurodegeneration in a fly model.
Sho Nakajima, Kotone Watanabe, Grigorii Sultanakhmetov, Aoi Fukuchi, Keiya Ito, Sawako Shimizu, Taro Saito, Akiko Asada, Kanae Ando   +8 more
wiley   +1 more source

Location of Trigger Points in a Group of Police Working Dogs: A Preliminary Study. [PDF]

Animals (Basel), 2023
Formenton MR, Portier K, Gaspar BR, Gauthier L, Yeng LT, Fantoni DT.   +5 more
europepmc   +1 more source