Results 131 to 140 of about 5,759,613 (298)
Macroeconomic impact from extending working lives (WP95) [PDF]
, 2011 This report presents findings from research, conducted by the National Institute of Economic and Social Research (NIESR) and funded by the Department for Work and Pensions (DWP).
Barrell, Ray, Kirby, S, Orazgani, Ali
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Molecular Oncology, EarlyView.Development of therapies targeting cancer‐associated fibroblasts (CAFs) necessitates preclinical model systems that faithfully represent CAF–tumor biology. We established an in vitro coculture system of patient‐derived pancreatic CAFs and tumor cell lines and demonstrated its recapitulation of primary CAF–tumor biology with single‐cell transcriptomics ...
Elysia Saputra +10 more
wiley +1 more source
Gender and educational differences in work participation and working years lost in Norway
Scandinavian Journal of Work, Environment & HealthOBJECTIVES: This study aimed to quantify the duration of work participation and reasons for working years lost, according to gender and educational attainment, among a Norwegian population.
Suzanne L Merkus +6 more
doaj +1 more source
Exciting discovery of previously unknown Katherine Mansfield manuscripts at the Newberry Library [PDF]
, 2015 It was whilst working my way through the rich holdings of Katherine Mansfield materials at the Newberry Library in May 2015 that I came across a thick folder of poems.
Kimber, Gerri
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Molecular Oncology, EarlyView.Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice +16 more
wiley +1 more source
Potential therapeutic targeting of BKCa channels in glioblastoma treatment
Molecular Oncology, EarlyView.This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak +4 more
wiley +1 more source
Back to the Future: Not looking into the Future but at Futures
Nordic Journal of Working Life Studies, 2015 Ann Bergman
doaj +1 more source
A handbook for the Africa Peace Tour [PDF]
, 1991 Documentation related to the Africa Peace Tour Handbook, which was aimed at helping US audiences understand the way US military involvement in Africa has a negative impact on wages, working conditions and the general quality of life in the US (looking at
Seidman, Ann, Seidman, Robert B.
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Exploiting metabolic adaptations to overcome dabrafenib treatment resistance in melanoma cells
Molecular Oncology, EarlyView.We show that dabrafenib‐resistant melanoma cells undergo mitochondrial remodeling, leading to elevated respiration and ROS production balanced by stronger antioxidant defenses. This altered redox state promotes survival despite mitochondrial damage but renders resistant cells highly vulnerable to ROS‐inducing compounds such as PEITC, highlighting redox
Silvia Eller +17 more
wiley +1 more source
Molecular Oncology, EarlyView.Pharmacologic ascorbate (vitamin C) increases ROS, disrupts cellular metabolism, and induces DNA damage in CRPC cells. These effects sensitize tumors to PARP inhibition, producing synergistic growth suppression with olaparib in vitro and significantly delayed tumor progression in vivo. Pyruvate rescue confirms ROS‐dependent activity.
Nicolas Gordon +13 more
wiley +1 more source