Results 91 to 100 of about 5,643,683 (390)

The epithelial barrier theory proposes a comprehensive explanation for the origins of allergic and other chronic noncommunicable diseases

FEBS Letters, EarlyView.
Exposure to common noxious agents (1), including allergens, pollutants, and micro‐nanoplastics, can cause epithelial barrier damage (2) in our body's protective linings. This may trigger an immune response to our microbiome (3). The epithelial barrier theory explains how this process can lead to chronic noncommunicable diseases (4) affecting organs ...
Can Zeyneloglu, Huseyn Babayev, Ismail Ogulur, Sena Ardicli, Yagiz Pat, Duygu Yazici, Bingjie Zhao, Lihong Chang, Xiaoqing Liu, Paolo D'Avino, Manru Li, Ceren Biçer, Fatma Hacer Kurtoğlu Babayev, Raja Dhir, Kari C. Nadeau, Marie‐Charlotte Brüggen, Mubeccel Akdis, Cezmi A. Akdis   +17 more
wiley   +1 more source

Multi‐omic characterization of consensus molecular subtype 1 (CMS1) colorectal cancer with dampened immune response improves precision medicine

Molecular Oncology, EarlyView.
This study highlights the importance of multi‐omic analyses in characterizing colorectal cancers. Indeed, our analysis revealed a rare CMS1 exhibiting dampened immune activation, including reduced PD‐1 expression, moderate CD8+ T‐cell infiltration, and suppressed JAK/STAT pathway.
Livia Concetti, Manuel Scimeca, Julia Bischof, Jonathan Woodsmith, Massimiliano Agostini, Cristina Fiorani, Yufang Shi, Eleonora Candi, Gerry Melino, Alessandro Mauriello, Giuseppe S. Sica   +10 more
wiley   +1 more source

Simple and Complex Working Memory Tasks Allow Similar Benefits of Information Compression

Journal of Cognition, 2018
Complex working memory span tasks were designed to engage multiple aspects of working memory and impose interleaved processing demands that limit the use of mnemonic strategies, such as chunking.
Fabien Mathy, Mustapha Chekaf, Nelson Cowan   +2 more
doaj   +1 more source

Onset of Mild Cognitive Impairment in Parkinson Disease [PDF]

, 2016
Objective: Characterize the onset and timing of cognitive decline in Parkinson disease (PD) from the first recognizable stage of cognitively symptomatic PD-mild cognitive impairment (PD-MCI) to PD dementia (PDD).
Barton, Biundo, Botwinick, Broeders, Cholerton, Cudeck, Dubois, Duncombe, Emre, Galvin, Galvin, Geurtsen, Goldman, Goldman, Hughes, Jack, Johnson, Johnson, Johnson, Lippa, Litvan, Marinelli, Marinelli, Morris, Muslimovic, Muslimovic, Pate, Petersen, Price, Reid, Slate, Stewart, Troncoso, Wang, Yarnall   +34 more
core   +2 more sources

Tumor clusters with divergent inflammation and human retroelement expression determine the clinical outcome of patients with serous ovarian cancer

Molecular Oncology, EarlyView.
Analysis of treatment‐naïve high‐grade serous ovarian carcinoma (HGSOC) and control tissues for ERVs, LINE‐1 (L1), inflammation, and immune checkpoints identified five clusters with diverse patient recurrence‐free survivals. An inflammation score was calculated and correlated with retroelement expression, where one novel cluster (Triple‐I) with high ...
Laura Glossner, Markus Eckstein, Christoph Mark, Matthias W. Beckmann, Arndt Hartmann, Pamela L. Strissel, Reiner Strick   +6 more
wiley   +1 more source

Working memory: Is it the new IQ? [PDF]

, 2008
Working memory, our ability to process and remember information, is linked to a range of cognitive activities from reasoning tasks to verbal comprehension. There is also extensive evidence of the relationship between working memory and learning outcomes.
Ross G. Alloway, Tracy Packiam Alloway
core   +1 more source

Small modifier, big decision: switching to SUMO mode adds weight to cancer stemness in mammary tumors

Molecular Oncology, EarlyView.
Inhibition of protein SUMOylation has been shown to block tumorigenesis; however, the specific mechanisms by which SUMOylation controls the tumor‐initiating capacities remain elusive. Li et al. describe the role of Etv1 SUMOylation in cancer stem cells using mouse models of mammary gland tumorigenesis.
Veronika Yevdokimova, Yannick D. Benoit
wiley   +1 more source

Understanding and measuring mechanical signals in the tumor stroma

FEBS Open Bio, EarlyView.
This review discusses cancer‐associated fibroblast subtypes and their functions, particularly in relation to extracellular matrix production, as well as the development of 3D models to study tumor stroma mechanics in vitro. Several quantitative techniques to measure tissue mechanical properties are also described, to emphasize the diagnostic and ...
Fàtima de la Jara Ortiz, Chiara Cimmino, Maurizio Ventre, Alessandra Cambi   +3 more
wiley   +1 more source

Uma introdução ao estudo cognitivo da memória a curto prazo: da teoria dos múltiplos armazenadores a memória de trabalho

Estudos de Psicologia (Campinas)
Este artigo apresenta uma revisão teórica dos principais estudos publicados a respeito do sistema de memória a curto prazo. A primeira parte deste artigo trata de uma revisão histórica do estudo da memória a curto prazo.
Márcia da Mota
doaj   +1 more source

The Impact of Auditory Working Memory Training on the Fronto-Parietal Working Memory Network

Frontiers in Human Neuroscience, 2012
Working memory training has been widely used to investigate working memory processes. We have shown previously that visual working memory benefits only from intra-modal visual but not from across-modal auditory working memory training.
Julia eSchneiders, Bertram eOpitz, Huijun eTang, Yuan eDeng, Chiaoxiang eXie, Hong eLi, Axel eMecklinger   +6 more
doaj   +1 more source