Tau acetylation at K331 has limited impact on tau pathology in vivo
FEBS Letters, EarlyView.We mapped tau post‐translational modifications in humanized MAPT knock‐in mice and in amyloid‐bearing double knock‐in mice. Acetylation within the repeat domain, particularly around K331, showed modest increases under amyloid pathology. To test functional relevance, we generated MAPTK331Q knock‐in mice.
Shoko Hashimoto +3 more
wiley +1 more source
Tractor engine load and fuel consumption in road construction works
Transport, 2010 Tractor load influences engine work parameters having an influence on the working economy and productivity of the complete tractor aggregate. The operational economy and productivity of the tractor is mostly evident when its engine power is utilized at ...
A. Janulevičius, A. Juostas, G. Pupinis
doaj
Working time variation and mental health during the Covid-19 pandemic in China. [PDF]
SSM Popul Health, 2023 Pan W, Jing FF, Liang Y.
europepmc +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Restorative Effects of Biophilic Workplace and Nature Exposure during Working Time: A Systematic Review. [PDF]
Int J Environ Res Public Health, 2023 Gonçalves G +4 more
europepmc +1 more source
Working long hours and having no choice : time poverty in Guinea [PDF]
This paper provides a new definition of'time poverty'as working long hours and having no choice to do otherwise. An individual is time poor if he/she is working long hours and is also monetary poor, or would fall into monetary poverty if he/she were to ...
Bardasi, Elena, Wodon, Quentin
core
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Current perceptions and working time models of female urologists in Germany: results of a large-scale survey. [PDF]
World J Urol, 2023 Weinberger S +10 more
europepmc +1 more source
New approaches to working time policy in Germany: The 28,8 hour working week at Volkswagen Company [PDF]
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Seifert, Hartmut, Trinczek, Rainer
core
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source