Results 171 to 180 of about 2,216,812 (309)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

Working Hour Arrangements and Working Hours A Microeconometric Analysis Based on German Time Diary Data

open access: yes
The labour market providing individual resources and economic well-being is still a topic in the economic and social policy discussion. In the course of time the traditional full-time work is diminishing, new labour arrangements are discussed (keyword ...
Burgert, Derik, Merz, Joachim
core  

WP RR 15 - Employees' preferences for more or fewer working hours: The effects of usual, contractual and standard working time, family phase and household characteristics and job satisfaction [PDF]

open access: yes
This study seeks explanations for working time preferences, using cross-sectional multinomial logits for the 2001/2002 Wage Indicator dataset (N=21,727). As expected, the preferences are predominately influenced by working hours’ characteristics, showing
Kea Tijdens
core  

[Flexible working time models in rheumatology : Results of a Germany-wide survey]. [PDF]

open access: yesZ Rheumatol
Pecher AC   +12 more
europepmc   +1 more source

Hippo pathway at the crossroads of stemness and therapeutic resistance in breast cancer

open access: yesMolecular Oncology, EarlyView.
Dysregulation of the Hippo pathway drives nuclear accumulation of YAP/TAZ, activating stemness‐related transcriptional programs that sustain breast cancer stemness and fuel therapeutic resistance across subtypes, underscoring Hippo signaling as a targetable vulnerability. Figure created and edited with BioRender.com.
Giulia Schiavoni   +11 more
wiley   +1 more source

The development and initial validation of a new working time scale for full-time workers with non-standard schedules. [PDF]

open access: yesBMC Public Health, 2022
Cavallari JM   +7 more
europepmc   +1 more source

Deciphering transcriptional plasticity in pancreatic ductal adenocarcinoma reveals alterations in sensory neuron innervation

open access: yesMolecular Oncology, EarlyView.
Pancreatic sensory neurons innervating healthy and PDAC tissue were retrogradely labeled and profiled by single‐cell RNA sequencing. Tumor‐associated innervation showed a dominant neurofilament‐positive subtype, altered mitochondrial gene signatures, and reduced non‐peptidergic neurons.
Elena Genova   +14 more
wiley   +1 more source

Flexible Working Hours and the Acceptance of Employment by Non-Working Mothers

open access: yes, 1982
The year given (1982) is an estimate.Flexible working hours have been recognized as one means by which conflict between personal life's demands and the demands associated with work can be reduced.
Pierce, Jon L, Kuhlmann, Diane O
core  

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