Molecular Oncology, EarlyView.Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary +1 more
wiley +1 more source
Effect of simulation-based stratified first aid training on physicians: a cohort study stratified by clinical working time and disciplinary background. [PDF]
BMC Med EducYang X +5 more
europepmc +1 more source
Spillover and crossover effects of working time demands on work-life balance satisfaction among dual-earner couples: the mediating role of work-family conflict. [PDF]
Curr Psychol, 2022 Lott Y, Wöhrmann A.
europepmc +1 more source
Towards a more rational and sustainable working time local and regional time agenda [PDF]
Pignon, T +3 more
core
Molecular Oncology, EarlyView.This study shows that lung adenocarcinomas exploit developmental branching morphogenesis to acquire a therapy resistant basal‐like tumour cell state. This process was found to be regulated by combined TP53 loss‐of‐function and type‐I interferon signalling, identifying a novel axis for biomarker and therapeutic target discovery.
Kamila J Bienkowska +13 more
wiley +1 more source
Commuting time and musculoskeletal pain in the relationship with working time: a cross-sectional study. [PDF]
Ann Occup Environ MedRyu H, Cho SS, Kim JI, Choi SH, Kim N.
europepmc +1 more source
Temporal Dimensions of Job Quality and Gender: Exploring Differences in the Associations of Working Time and Health between Women and Men. [PDF]
Int J Environ Res Public Health, 2022 Franklin P, Zwysen W, Piasna A.
europepmc +1 more source
Molecular Oncology, EarlyView.Combining osimertinib with the STING agonist ADU‐S100 activates innate and adaptive immunity to overcome the non‐inflamed microenvironment of Egfr‐mutant lung cancer. This combination increases NK and CD8+ T‐cell infiltration, associated with activation of the STING‐IRF3 pathway and local immunogenic cell death.
Jun Nishimura +19 more
wiley +1 more source
GP working time and supply, and patient demand in England in 2015-2022: a retrospective study. [PDF]
Br J Gen PractParisi R +9 more
europepmc +1 more source
Loss of IGF‐1R impairs DNA‐PKcs recruitment to chromatin leading to defective end‐joining
Molecular Oncology, EarlyView.IGF‐1R promotes radioresistance by facilitating DNA‐PKcs recruitment to chromatin, enabling non‐homologous end‐joining (NHEJ) repair of double‐strand breaks. Inhibition or loss of IGF‐1R disrupts this recruitment to damage sites, driving compensatory reliance on microhomology‐mediated end‐joining (MMEJ) repair.
Matthew O. Ellis +3 more
wiley +1 more source