Results 201 to 210 of about 2,216,812 (309)

Teachers' working time as a risk factor for their mental health - findings from a cross-sectional study at German upper-level secondary schools. [PDF]

BMC Public Health, 2022
Kreuzfeld S, Felsing C, Seibt R.
europepmc   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Towards a more rational and sustainable working time local and regional time agenda [PDF]

Pignon, T, García Ruiz, N, Arntsen, A, Junqué Surià, M   +3 more
core  

Interpreting the effects of DNA polymerase variants at the structural level

Molecular Oncology, EarlyView.
Using MAVISp and molecular dynamics simulations, we analyzed over 60 000 missense variants in POLE and POLD1 from ClinVar, COSMIC, cBioPortal, and saturation mutagenesis. Identified mechanistic indicators, including stability, binding, and long‐range, enable structural interpretation, providing ACMG‐like evidence for possible reclassification of VUS ...
Matteo Arnaudi, Karolina Krzesińska, Ludovica Beltrame, Pablo Sánchez‐Izquierdo Besora, Matteo Tiberti, Mef Nilbert, Anna Rohlin, Elena Papaleo   +7 more
wiley   +1 more source

Preferred Working Time Models and Equal Opportunities in Gynecology and Obstetrics: Results of the Systematic Trinational FARBEN Survey. [PDF]

Geburtshilfe Frauenheilkd
Tauber N, Amann N, Foessleitner P, Klee A, Becker C, Kiblawi R, Göpfert M, Kiessling N, Taumberger N, Beizermann E, Krawczyk N, Simowitsch S, Schmalfeldt B, Toth B, Müller M, Weiss M, Reiser E, Eggimann T, Rody A, Banys-Paluchowski M.   +19 more
europepmc   +1 more source

Changes in weekly working hours, proportion of doctors with hours above the limitations of European Working Time Directive (EWTD) and time spent on direct patient care for doctors in Norway from 2016 to 2019: a study based on repeated surveys. [PDF]

BMJ Open, 2023
Rosta J, Rø KI.
europepmc   +1 more source

Proteasome inhibitor, ixazomib prevents topoisomerase‐I degradation and reverses irinotecan resistance in colorectal cancer

Molecular Oncology, EarlyView.
Ixazomib inhibits proteasome‐mediated degradation of topoisomerase I induced by irinotecan, thereby restoring drug sensitivity and promoting tumor cell death in colorectal cancer. Irinotecan, a topoisomerase I (topoI) inhibitor, is widely used for colorectal cancer, but resistance remains a major clinical challenge.
Yuho Ebata, Koji Ando, Hirofumi Hasuda, Koshi Mimori, Elizabeth C. Unan, Siddhartha Pulukuri, Aahana Tiku, Allison Berger, Eiji Oki, Ajit Bharti, Tomoharu Yoshizumi   +10 more
wiley   +1 more source

Psychosocial demands and resources for working time organization in GP practices. Results from a team-based ethnographic study in Germany. [PDF]

J Occup Med Toxicol, 2021
Preiser C, Tsarouha E, Weltermann B, Junne F, Seifried-Dübon T, Hartmann S, Bleckwenn M, Rieger MA, Rind E, IMPROVEjob-Consortium.   +9 more
europepmc   +1 more source

Metastasis on pause: How dormant tumor cells stay hidden within the tumor microenvironment and evade immune surveillance

Molecular Oncology, EarlyView.
Dormant cancer cells can hide in distant organs for years, evading treatment and the immune system. This review highlights how signals from the surrounding tissue and immune environment keep these cells inactive or trigger their reawakening. Understanding these mechanisms may help develop therapies to eliminate or control dormant cells and prevent ...
Kanishka Tiwary, Jose Javier Bravo‐Cordero   +1 more
wiley   +1 more source

How does working time impact perceived mental disorders? New insights into the U-shaped relationship. [PDF]

Front Public Health
Niu X, Li C, Xia Y.
europepmc   +1 more source