Results 61 to 70 of about 19,514,315 (299)
FEBS Letters, EarlyView.Enteropathogenic E. coli (EPEC) infects the human intestinal epithelium, resulting in severe illness and diarrhoea. In this study, we compared the infection of cancer‐derived cell lines with human organoid‐derived models of the small intestine. We observed a delayed in attachment, inflammation and cell death on primary cells, indicating that host ...
Mastura Neyazi +5 more
wiley +1 more source
Organoids in pediatric cancer research
FEBS Letters, EarlyView.Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley +1 more source
Overtime Work Flexibility in Baltic States
Law: Journal of the University of Latvia, 2022 This paper gives an overview of how well the Baltic States have introduced the European flexibility policy in their overtime work regulations, to meet the goals of European Commission strategy “Europe 2020”.
Agne Kalson
doaj
FEBS Letters, EarlyView.Structural and biochemical characterisations show that the planar cell polarity (PCP) protein Inturned harbours a unique PDZ‐like domain that does not bind canonical PDZ‐binding motifs (PBMs) like that of another PCP protein Vangl2. In contrast, the apical‐basal polarity protein Scribble contains four PDZ domains that bind Vangl2, but one PDZ domain ...
Stephan Wilmes +4 more
wiley +1 more source
Review of European and Comparative LawThe recognition of rights to limited working hours, rest, and leisure was preceded by a long struggle by workers to shorten their working time. International organizations also contributed to this process, notably by establishing standards designed to ...
Ljubinka Kovacevic
doaj +1 more source
Calpain small subunit homodimerization is robust and calcium‐independent
FEBS Letters, EarlyView.Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy +4 more
wiley +1 more source
Structural insights into an engineered feruloyl esterase with improved MHET degrading properties
FEBS Letters, EarlyView.A feruloyl esterase was engineered to mimic key features of MHETase, enhancing the degradation of PET oligomers. Structural and computational analysis reveal how a point mutation stabilizes the active site and reshapes the binding cleft, expading substrate scope.
Panagiota Karampa +5 more
wiley +1 more source
Long working hours and preventive oral health behaviors: a nationwide study in Korea (2007–2021)
Environmental Health and Preventive MedicineBackground: This study explored the association between working hours and preventive oral health behaviors. Methods: In total, 48,599 workers (22,992 females) were included from the Korea National Health and Nutrition Examination Survey (2007–2021 ...
Seong-Uk Baek +3 more
doaj +1 more source
Scandinavian Journal of Work, Environment & Health, 2018 OBJECTIVES: The present study examined hemodynamic responses of normotensive and untreated hypertensive participants under simulated long working hours (LWH) – 13 hours – in an experimental laboratory study.
Hiroki Ikeda +4 more
doaj +1 more source
Gut microbiome and aging—A dynamic interplay of microbes, metabolites, and the immune system
FEBS Letters, EarlyView.Age‐dependent shifts in microbial communities engender shifts in microbial metabolite profiles. These in turn drive shifts in barrier surface permeability of the gut and brain and induce immune activation. When paired with preexisting age‐related chronic inflammation this increases the risk of neuroinflammation and neurodegenerative diseases.
Aaron Mehl, Eran Blacher
wiley +1 more source