Results 61 to 70 of about 2,814,958 (312)

Longitudinal circulating tumor DNA profiling in patients with advanced endometrial cancer using an off‐the‐shelf targeted NGS panel

Molecular Oncology, EarlyView.
Intratumour heterogeneity complicates precision management of advanced endometrial cancer. Circulating tumor DNA (ctDNA) offers a minimally invasive strategy to capture tumor evolution and therapeutic resistance. Here, we compare tumor‐agnostic NGS with tumor‐informed ddPCR, outlining their relative sensitivity, concordance, and clinical implications ...
Carlos Casas‐Arozamena, Karin Teien Lande, Eva Diaz, Ana Vilar, Juan Cueva, Efigenia Arias, Victoria Sampayo, Alicia Abalo, Nerea González, Eva Colás, Antonio Gil‐Moreno, Miguel Abal, Gema Moreno‐Bueno, Therese Sørlie, Kristina Lindemann, Laura Muinelo‐Romay   +15 more
wiley   +1 more source

Interaction of HS1BP3 with cortactin modulates TKS5 localisation, cell secretion and cancer malignancy

Molecular Oncology, EarlyView.
Here, we demonstrate that HS1BP3 interacts with Cortactin through a proline‐rich region (PRR3.1) and show that this interaction, and HS1BP3 itself, promote cancer cell proliferation and invasion. Inhibition of this interaction leads to build‐up of TKS5 in multivesicular endosomes and altered secretion of CD63 and CD9, providing an explanation for the ...
Arja Arnesen Løchen, Kristiane Søreng, Chiara Veroni, Laura Trachsel‐Moncho, Nagham Asp, Robin Gaupset, Lars Gustav Lyckander, Helene Knævelsrud, Lars Eftang, Anne Simonsen   +9 more
wiley   +1 more source

Impact of the COVID-19 pandemic on the mental and physical health of Indian working women: A cross-sectional study of District Rajkot, Gujarat [PDF]

GIornale Italiano di Psicologia e Medicina del Lavoro
Introduction: The COVID-19 pandemic has profoundly affected societies and economies worldwide, with working women facing unique challenges. This study aimed to analyze changes in the employment status of working women before and after the COVID-19 ...
Thakur Dev PANDEY, Jyoti PATHAK
doaj   +1 more source

Challenging gender myths: Promoting inclusive wheat and maize research for development in Nepal [PDF]

, 2020
This technical note provides research evidence debunking four gender myths: 1) men are the main decision makers; 2) women don’t do much in wheat and maize; 3) women don’t innovate; and 4) women lack resources for innovation.
Badstue, Lone B., Chatterjee, Sushila, Farnworth, Cathy R., Jafry, Tahseen, Lama, Kanchan   +4 more
core  

Targeting TNBC: core–shell polycationic polyurea dendrimers with inherent anticancer activity

FEBS Open Bio, EarlyView.
Core–shell polycationic PURE dendrimers were tested in TNBC‐derived tumor models. Both formulations selectively targeted TNBC and effectively reduced tumor volume. PUREG4‐OEI48 suppressed tumor growth without detectable toxicity, whereas PUREG4‐OCEI24, despite showing efficacy, induced hepatic toxicity.
Adriana Cruz, Bruna Abreu, Cindy Mendes, Catarina Freitas‐Dias, Filipe Gonçalves, Fernanda Silva, José Ramalho, Saudade André, Vasco D. B. Bonifácio, Jacinta Serpa   +9 more
wiley   +1 more source

A inserção feminina no mercado de trabalho e suas implicações para os hábitos alimentares da mulher e de sua família

Saúde em Debate
Este estudo analisou os hábitos alimentares de mulheres inseridas no mercado de trabalho formal e de suas famílias. A pesquisa foi realizada na cidade de Viçosa/MG. A amostra foi de 101 mulheres.
Cristina Teixeira Lelis, Karla Maria Damiano Teixeira, Neuza Maria da Silva   +2 more
doaj   +2 more sources

Structural Model of Health-Promoting Lifestyle based on Self-Compassion, Satisfaction and Frustration of Basic Psychological needs: The Mediating Role of Perceived Stress in Working Women [PDF]

فصلنامه زن و جامعه
Introduction: The aim of this study was to investigate the relationship between satisfaction and frustration of basic psychological needs and self-compassion with health promoting lifestyle, considering the mediating role of perceived stress in working ...
Maryam Nateghi, Shirin Kooshki, Mohtaram Nemattavousi   +2 more
doaj   +1 more source

Effects of living in the same region as one’s workplace on the total fertility rate of working women in Korea [PDF]

Epidemiology and Health, 2019
OBJECTIVES The lowest-low fertility status of Korea has continued for the past 17 years despite governmental efforts to encourage childbirth. As the number of working women has increased, their residence patterns have changed; however, the impact of this
Yeon-Yong Kim, Hee-Jin Kang, Seongjun Ha, Jong Heon Park   +3 more
doaj   +1 more source

Engineering tandem VHHs to target different epitopes to enhance antibody‐dependent cell‐mediated cytotoxicity

FEBS Open Bio, EarlyView.
Tandem VHH targeting distinct EGFR epitopes were engineered into a monovalent bispecific antibody (7D12‐EGA1‐Fc) with more potent ADCC without increasing affinity to EGFR. Structural modeling of 7D12‐EGA1‐Fc showed cross‐linking of separate EGFR domains to enhance CD16a engagement on NK cells.
Yuqiang Xu, Hao Jiang, Limin Chen, Fulai Zhou, Ying Jin, Mark L. Chiu   +5 more
wiley   +1 more source

Labour Force Participation of Women Over 45 [PDF]

This Productivity Commission staff working paper (by Geoff Gilfillan and Les Andrews) was released in January 2011. The contribution of mature aged women (aged 45 to 64 years) to total hours worked in the economy by people of working age has increased ...
G, Gilfillan, L, Andrews
core   +1 more source