Results 41 to 50 of about 616,551 (309)

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

In Cuba They're Still Reading

Information for Social Change, 1996
In spite of over 30 years of being blockaded, literacy in Cuba has gone up from 1. 9 per cent before the Revolution to 98 per cent. In nearby Haiti 80 per cent of the population are illiterate.
John Pateman
doaj   +1 more source

Perceived income adequacy, family support, financial anxiety, and tax non-compliance of Indonesian working women during the Covid-19 pandemic

Business: Theory and Practice, 2023
In high-risk situations like the Covid-19 epidemic, it is believed that perceived income adequacy, family support,financial anxiety, and tax non-compliance have a strong relationship.
Priandhita Sukowidyanti Asmoro
doaj   +1 more source

Working Women in the Sandwich Generation [PDF]

, 2022
Women more often than men take care of their ageing relatives together with their own children or grandchildren. These Sandwich Generation (SG) women constitute an expanding vulnerable group on the labour market at higher risk of discrimination, work ...
Rajahonka, Mervi, Kwiatkowska-Ciotucha, Dorota, Villman, Kaija, Gielens, Tim, Lengeler, Veerle, Załuska, Urszula, Timmers, Miet   +6 more
core  

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

The Development of Nominal Synsets for the Saraiki Language: A Corpus-based Analysis

NUML Journal of Critical Inquiry
This paper focuses on developing nominal synsets for the Saraiki language (SL), a lesser-studied language spoken in Pakistan. Nominal synsets are groups of nouns that share semantic characteristics and are crucial for natural language processing tasks ...
Madya Asgher, Musarrat Azher
doaj   +1 more source

Individual and organizational factors related to social vitality of women working in Birjand University of Medical Sciences, Iran, in 2020

مجله دانشگاه علوم پزشکی بیرجند, 2021
Background and Aims: Happiness and vitality are among the most important and effective components in the process of human life, without which activity, creativity, initiative, invention, and healthy life cannot be created.
Maryam Bahlgerdi, Mohammadreza Miri, Enseiye Norozi, Gholamreza Sharifzadeh   +3 more
doaj  

Pengaruh Asupan Protein dan Zat Besi (Fe) terhadap Kadar Hemoglobin pada Wanita Bekerja

Jurnal Kesehatan, 2017
Anemia is a condition where the hemoglobin (Hb) is lower than the normal value according to age and sex of a person caused by certain factors, including intake of nutrients one protein and iron, with the percentage of women in Indonesia who have anemia ...
Agus Hendra Al Rahmad
doaj   +1 more source

OBESITY AND MARITAL RELATIONSHIP: THE MEDIATING ROLE OF COPING

Khyber Medical University Journal, 2022
OBJECTIVE: To find out the mediating role of coping between factors of obesity and marital relationship in women with obesity. METHODS: This analytical cross-sectional study was conducted from May to November 2019 at various universities (Lahore ...
Saima Ahmad Din, Amina Muazzam
doaj   +1 more source

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

Molecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric, Line Bjørge, Martine Rott Lode, Cecilie Fredvik Torkildsen, Pia Aehnlich, Rammah Elnour, Daniela Elena Costea, Lars Andreas Akslen, Liv Cecilie Vestrheim Thomsen, Emmet McCormack, Katrin Kleinmanns   +10 more
wiley   +1 more source