Results 71 to 80 of about 333,323 (263)

Günter Lüling

Al-'Usur al-Wusta, 2017
Dr. Günter Lüling, author of a number of revisionist works on the Qur’ān and the history of Islam’s origins, died on 10 September 2014, in Wasserburg am Inn, Germany.
Fred M. Donner
doaj   +1 more source

Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity

Molecular Oncology, EarlyView.
Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung, David Bickel, Lena C. M. Krause, Daria Ezeriņa, Christian Ickes, Julian Wojtachnia, Christine S. Gibhardt, Magdalena Shumanska, Khadija Wahni, Andrea Paluschkiwitz, Julia Malo Pueyo, Ekaterina Baranova, Wim Vranken, Hedwig Stanisz, Ioana Stejerean‐Todoran, Michael P. Schön, Joris Messens, Ivan Bogeski   +17 more
wiley   +1 more source

Hemingway: Works and Days

English Language and Literature Studies, 2013
Considering Hemingway’s life and activities in different period of his life is one of the important legal issues that have gained particular significance of the reflection on his life on his works. So the later years of Hemingway’s life (1948-1962) are examined.
openaire   +1 more source

Crucial parameters for precise copy number variation detection in formalin‐fixed paraffin‐embedded solid cancer samples

Molecular Oncology, EarlyView.
This study shows that copy number variations (CNVs) can be reliably detected in formalin‐fixed paraffin‐embedded (FFPE) solid cancer samples using ultra‐low‐pass whole‐genome sequencing, provided that key (pre)‐analytical parameters are optimized.
Hanne Goris, Vasiliki Siozopoulou, Léon C van Kempen, Anne Sieben, Ella Roelant, Stig Hellemans, Elyne Backx, Laure Sorber, Koen De Winne, Senada Koljenović, Karen Zwaenepoel   +10 more
wiley   +1 more source

THE DAILY LIFE OF THE OLD ISTANBUL REFLECTED IN THE MANSION OF IBRAHIM EFENDI

Zeitschrift für die Welt der Türken, 2015
Samiha Ayverdi is a writer who had important contribution in Turkish literature producing thirty six works. Ayverdi, during her lifetime witnessed Balkan war, Tripoli war, World War, War of Independence Westernization process was experienced in all its ...
Sevgül TÜRKMENOĞLU
doaj  

Crypto Art (NFTs) and a Post-Truth World

Art Time
Globalization aims to create a uniform world by bringing together the cultural, social and individual differences of people historically. In this process, original works of art, ideas and traditions that have emerged in different geographies and cultures
Mehmet Sabri Genç
doaj   +1 more source

Combining antibody conjugates with cytotoxic and immune‐stimulating payloads maximizes anti‐cancer activity

Molecular Oncology, EarlyView.
Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang, Dong Jun Koo, Peter M. Tessier, Greg M. Thurber   +3 more
wiley   +1 more source

Bowdlerizing or maximizing? Two strategies to render Shakespeare’s sexual puns In nineteenth-century spain Bowdlerizing or maximizing? Two strategies to render Shakespeare’s sexual puns In nineteenth-century spain

Ilha do Desterro, 2008
In 1883, Ricardo de Miranda, Marqués de Premio Real, addressed a letter to poet and novelist Emilia Pardo Bazán in the newspaper La Época.2 In this letter, Miranda argued Zola’s “immoral naturalism” was lacking in English novelists and playwrights, whose
Laura Campillo Arnaiz
doaj  

TRAIL‐PEG‐Apt‐PLGA nanosystem as an aptamer‐targeted drug delivery system potential for triple‐negative breast cancer therapy using in vivo mouse model

Molecular Oncology, EarlyView.
Aptamers are used both therapeutically and as targeting agents in cancer treatment. We developed an aptamer‐targeted PLGA–TRAIL nanosystem that exhibited superior therapeutic efficacy in NOD/SCID breast cancer models. This nanosystem represents a novel biotechnological drug candidate for suppressing resistance development in breast cancer.
Gulen Melike Demirbolat, Aslihan Kucuk, Omer Erdogan, Samed Ozer, Bensu Kozan, Tugba Cuceli, Erkan Gumus, Evrim Cevik, Ozge Cevik   +8 more
wiley   +1 more source

The PI3Kδ inhibitor roginolisib (IOA‐244) preserves T‐cell function and activity

Molecular Oncology, EarlyView.
Identification of novel PI3K inhibitors with limited immune‐related adverse effects is highly sought after. We found that roginolisib and idelalisib inhibit chronic lymphocytic leukemia (CLL) cells and Treg suppressive functions to similar extents, but roginolisib affects cytotoxic T‐cell function and promotion of pro‐inflammatory T helper subsets to a
Elise Solli, Alessio Bevilacqua, Mathias Wenes, Denis Migliorini, Lars van der Veen, Sigrid S Skånland, Giusy Di Conza, Kjetil Taskén   +7 more
wiley   +1 more source