Results 41 to 50 of about 4,344,720 (316)

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

2013 Economic Developer of the Year Award Winners

Journal of Aboriginal Economic Development, 2014
Dakota Dunes Hotel development; Dakota Dunes Golf Links expansion for a Club House; Saskatoon Tribal Council Casino Holdings, and; Whitecap Commercial Real Estate development.
Morgan Bamford, Michelle White-Wilsdon
doaj   +1 more source

Transferrin receptor 1‐mediated iron uptake supports thermogenic activation in human cervical‐derived adipocytes

FEBS Letters, EarlyView.
In this study, we found that human cervical‐derived adipocytes maintain intracellular iron level by regulating the expression of iron transport‐related proteins during adrenergic stimulation. Melanotransferrin is predicted to interact with transferrin receptor 1 based on in silico analysis.
Rahaf Alrifai, Mizuki Seo, Gyath Karadsheh, Fachrur Rizal Mahendra, Máté Á Demény, Ferenc Győry, János András Mótyán, László Fésüs, Endre Kristóf, Rini Arianti   +9 more
wiley   +1 more source

Personnel adjustments during the Covid-19 pandemic: did co-determination make a difference?

Journal for Labour Market Research
Using a unique dataset of establishments in Germany surveyed during the Covid-19 pandemic, this study investigates whether personnel adjustments during the crisis differed between establishments with and without a works council.
Daniel Fackler, Claus Schnabel, Jens Stegmaier   +2 more
doaj   +1 more source

Works Councils and Separations: Voice, Monopoly, and Insurance Effects [PDF]

Using a large linked employer-employee data set for Germany, we find that the existence of a works council is associated with a lower separation rate to employment, in particular for men and workers with low tenure.
Hirsch, Boris, Schank, Thorsten, Schnabel, Claus   +2 more
core   +3 more sources

Calpain small subunit homodimerization is robust and calcium‐independent

FEBS Letters, EarlyView.
Calpains dimerize via penta‐EF‐hand (PEF) domains. Using single‐molecule force spectroscopy, we measured the strength and kinetics of PEF–PEF homodimer binding. The interaction is robust, shows a transient conformational step before dissociation, and remains largely insensitive to Ca2+.
Nesha May O. Andoy, Trina Dykstra‐MacPherson, Mathias A. Bell, Peter L. Davies, Ruby May A. Sullan   +4 more
wiley   +1 more source

Diversity and complexity in neural organoids

FEBS Letters, EarlyView.
Neural organoid research aims to expand genetic diversity on one side and increase tissue complexity on the other. Chimeroids integrate multiple donor genomes within single organoids. Self‐organising multi‐identity organoids, exogenous cell seeding, or enforced assembly of region‐specific organoids contribute to tissue complexity.
Ilaria Chiaradia, Madeline A. Lancaster
wiley   +1 more source

Electronic bidding in the Contract of Public Works in the Palestinian Legislative Council

دراسات: علوم الشريعة والقانون, 2020
This study deals with the issue of electronic bidding in the government public works contract. The main problem of the study is in determining the legal nature of the subject of electronic bidding in the public works contract, and the extent to which it
Abdullah. D. Mahmoud, Osama. I. Darraj   +1 more
doaj  

La peste de 1599 en Burgos, una relación del regidor Andrés de Cañas

Brocar. Cuadernos de investigación histórica, 1987
Although it is not our main purpose to publish original documents, we do so in this case due to the importance -and the difficult access to the document- of this material and also for the importance of the notes which accompany it.
Francis Brumont
doaj   +1 more source