Results 71 to 80 of about 4,344,720 (316)

Establishment of a humanized patient‐derived xenograft mouse model of high‐grade serous ovarian cancer for preclinical evaluation of combination immunotherapy

open access: yesMolecular Oncology, EarlyView.
We have established a humanized orthotopic patient‐derived xenograft (Hu‐oPDX) mouse model of high‐grade serous ovarian cancer (HGSOC) that recapitulates human tumor–immune interactions. Using combined anti‐PD‐L1/anti‐CD73 immunotherapy, we demonstrate the model's improved biological relevance and enhanced translational value for preclinical ...
Luka Tandaric   +10 more
wiley   +1 more source

D. Geraldo de Proença Sigaud e as direitas católicas contra as inovações do Concílio Vaticano II

open access: yesNuevo mundo - Mundos Nuevos, 2016
By exhaustively investigating the personal files of one the most polemic Brazilians bishops of the 20th century, Mr. Geraldo de Proença Sigaud (1909 – 1999), important contacts with American anti-communist groups the bishop of Diamantina (Minas Gerais ...
Rodrigo Coppe Caldeira
doaj   +1 more source

CCDC80 suppresses high‐grade serous ovarian cancer migration via negative regulation of B7‐H3

open access: yesMolecular Oncology, EarlyView.
PAX8 is a lineage‐specific master regulator of transcription in high‐grade serous ovarian cancer (HGSC) progression. We show for the first time that PAX8 facilitates proliferation and metastasis by repressing the cell autonomous tumor suppressor CCDC80 and inducing B7‐H3 expression.
Aya Saleh   +12 more
wiley   +1 more source

German Works Councils and The Anatomy of Wages [PDF]

open access: yes
This paper provides the first comprehensive examination of the effect of German works councils on wages, using matched employer-employee data from the German LIAB for 2001. We find that works councils are associated with higher earnings: the wage premium
John T. Addison   +2 more
core   +3 more sources

Wybrane aspekty odnowy liturgii w teologicznej refleksji Josepha Ratzingera pięćdziesiąt lat od zakończenia II Soboru Watykańskiego

open access: yesWrocławski Przegląd Teologiczny, 2016
Fiftieth anniversary of completing the II Vatican Council works allows us to look critically on theology and the post-conciliar achievements in topic of liturgy.
Paweł Beyga
doaj   +1 more source

German works councils in the production process [PDF]

open access: yes
We estimate the effects of works councils on productivity, 1997-2000, using the IAB Establishment Panel, a nationally representative German data set.
Addison, John T.   +3 more
core  

CD47 promotes mitogen‐activated protein kinase and epithelial‐to‐mesenchymal transition molecular programs to drive prometastatic phenotypes in non‐small cell lung cancer

open access: yesMolecular Oncology, EarlyView.
Beyond its role in immune evasion, this study identified that CD47 drives tumor‐intrinsic signaling in non‐small cell lung cancer (NSCLC). Transcriptomic profiling and functional studies revealed that CD47 regulates cell adhesion, migration, and metastasis through an ERK–EMT signaling axis.
Asa P.Y. Lau   +8 more
wiley   +1 more source

The course of research into the economic consequences of German works councils [PDF]

open access: yes
In a recent survey, Frege (2002) concludes that economic analysis of the works council has reached a `dead end´. The present treatment offers a different conclusion based on a more encompassing review of the evidence.
Addison, John T.   +2 more
core  

Rent Seeking at Plant Level: An Application of the Card-De la Rica Tenure Model to Workers in German Works Councils [PDF]

open access: yes
Low-skilled workers enjoy a large wage advantage in German works council establishments. Since job tenure is also longer for these workers, one explanation might be rent-seeking.
John T. Addison   +2 more
core   +3 more sources

Cell‐cycle‐specific lesion evolution rather than inhibition of double‐strand‐break repair underpins cisplatin radiosensitization

open access: yesMolecular Oncology, EarlyView.
We analyze cisplatin–DNA adducts (CDAs) and double‐strand breaks (DSBs) in a cell‐cycle‐dependent manner. We find that CDAs form similarly across all cell cycle phases. DSBs arise only in S‐phase. CDAs might not directly impair DSB repair, but S‐phase DSB lesions evolve in the presence of CDAs and disrupt repair in G2, also causing radiosensitization ...
Ye Qiu   +10 more
wiley   +1 more source

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