Results 51 to 60 of about 270,436 (345)

Cell wall target fragment discovery using a low‐cost, minimal fragment library

FEBS Letters, EarlyView.
LoCoFrag100 is a fragment library made up of 100 different compounds. Similarity between the fragments is minimized and 10 different fragments are mixed into a single cocktail, which is soaked to protein crystals. These crystals are analysed by X‐ray crystallography, revealing the binding modes of the bound fragment ligands.
Kaizhou Yan, Mathew Stanley, Olawale Raimi, Andrew T. Ferenbach, Helge C Dorfmueller, Daan M. F. van Aalten   +5 more
wiley   +1 more source

Test and arbitration ruling in the cutting of town councils’ woodland property under the forestry administration of some Regions

Forest@, 2012
Testing the cutting of town councils’ woodland property is considered, according to the contractual clause imposed by the forestry administration of some Regions, arbitration ruling and is not subject to recourse or appeal. From historical research,
Fiorucci E
doaj   +1 more source

Cell density–dependent nuclear‐cytoplasmic shuttling of SETDB1 integrates with Hippo signaling to regulate YAP1‐mediated transcription

FEBS Letters, EarlyView.
At low cell density, SETDB1 and YAP1 accumulate in the nucleus. As cell density increases, the Hippo pathway is gradually activated, and SETDB1 is associated with increased YAP1 phosphorylation. At high cell density, phosphorylated YAP1 is sequestered in the cytoplasm, while SETDB1 becomes polyubiquitinated and degraded by the ubiquitin–proteasome ...
Jaemin Eom, Jaewoong Jang, Jung Sun Park, Yong‐Kook Kang   +3 more
wiley   +1 more source

Modeling hepatic fibrosis in TP53 knockout iPSC‐derived human liver organoids

Molecular Oncology, EarlyView.
This study developed iPSC‐derived human liver organoids with TP53 gene knockout to model human liver fibrosis. These organoids showed elevated myofibroblast activation, early disease markers, and advanced fibrotic hallmarks. The use of profibrotic differentiation medium further amplified the fibrotic signature seen in the organoids.
Mustafa Karabicici, Soheil Akbari, Ceyda Caliskan, Canan Celiker, Ozden Oz, Leman Binokay, Gökhan Karakulah, Serif Senturk, Esra Erdal   +8 more
wiley   +1 more source

A synthetic benzoxazine dimer derivative targets c‐Myc to inhibit colorectal cancer progression

Molecular Oncology, EarlyView.
Benzoxazine dimer derivatives bind to the bHLH‐LZ region of c‐Myc, disrupting c‐Myc/MAX complexes, which are evaluated from SAR analysis. This increases ubiquitination and reduces cellular c‐Myc. Impairing DNA repair mechanisms is shown through proteomic analysis.
Nicharat Sriratanasak, Bodee Nutho, Worawat Wattanathana, Narumon Phaonakrop, Bunnatut Panasawatwong, Katharina Erlenbach‐Wuensch, Sittiruk Roytrakul, Regine Schneider‐Stock, Pithi Chanvorachote   +8 more
wiley   +1 more source

Owner-Managers and the Failure of Newly Adopted Work Councils [PDF]

, 2016
Using representative data from the IAB Establishment Panel, we show that the managerial environment has a strong influence on the introduction and survival of works councils.
Addison, Addison, Addison, Addison, Askildsen, Backes-Gellner, Backes-Gellner, Baert, Baron, Belfield, Benz, Berger, Berger, Berle, Bertrand, Bormann, Braendle, Burgess, Chi, Cornelissen, Cullinane, Daeubler, Demsetz, Dilger, Drago, Eaton, Ellguth, Feinberg, Fiorito, Fiorito, Fischer, Freeman, Frege, Frick, Fuchs-Schuendeln, Gall, Godard, Greene, Grund, Hausman, Heywood, Heywood, Heywood, Heywood, Huebler, Huebler, Ichniowski, Jackson, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Jirjahn, Judd, Kassouf, Keller, King, King, Lee, Logan, Machin, Machin, Mohrenweiser, Mohrenweiser, Mueller, Mueller-Jentsch, Oberfichtner, Olsen, Pfeifer, Pfeifer, Pfeifer, Polzer, Renaud, Rheinisches Journalistenbuero (Werner Balsen, Hans Nakielski, Karl Roessel and Rolf Winkel), Roosenboom, Royle, Rudolph, Schloemer-Laufen, Schloemer-Laufen, Singell, Smith, Smith, Stettes, Wagner, Wagner, Wilde, Wilkesmann, Woessmann, Zwick, Zwick, Zwick   +98 more
core   +1 more source

Adaptaquin is selectively toxic to glioma stem cells through disruption of iron and cholesterol metabolism

Molecular Oncology, EarlyView.
Adaptaquin selectively kills glioma stem cells while sparing differentiated brain cells. Transcriptomic and proteomic analyses show Adaptaquin disrupts iron and cholesterol homeostasis, with iron chelation amplifying cytotoxicity via cholesterol depletion, mitochondrial dysfunction, and elevated reactive oxygen species.
Adrien M. Vaquié, Davod R. Shah, Eliane E. S. Brechbühl, Michael McNicholas, Zhaoyang Xu, John H. Stockley, Laura Morcom, Diana Gold Diaz, Gemma C. Girdler, Rachel V. Seear, Gabriel Balmus, Rajiv R. Ratan, Harry Bulstrode, James A. Nathan, Manav Pathania, Kevin M. Brindle, David H. Rowitch   +16 more
wiley   +1 more source

Personnel adjustments during the Covid-19 pandemic: did co-determination make a difference?

Journal for Labour Market Research
Using a unique dataset of establishments in Germany surveyed during the Covid-19 pandemic, this study investigates whether personnel adjustments during the crisis differed between establishments with and without a works council.
Daniel Fackler, Claus Schnabel, Jens Stegmaier   +2 more
doaj   +1 more source

Agricultural counselling as a form of adult education in Poland in 1956–1970

Rocznik Andragogiczny, 2015
The article presents issues relating to agricultural counselling as a form of out-of-school adult agricultural education in Poland in 1956–1970. In that time agricultural counselling was provided mainly by communal agronomists, instructors of National ...
Jan Wnęk
doaj   +1 more source

Higher wages, overstaffing or both? [PDF]

, 2012
This study examines the differences in the likelihood of overpayment and overemployment in establishments with and without works councils. In contrast to other studies, we use assessments by the management concerning the existence of such problems ...
Gralla, Rafael, Kraft, Kornelius
core