Results 81 to 90 of about 270,436 (345)
A subset of MMR‐proficient colon cancers responds to neoadjuvant immunotherapy
Molecular Oncology, EarlyView.Tan et al. reveal that a distinct subset of early‐stage pMMR colon cancers can respond to neoadjuvant immunotherapy. In the NICHE‐2 trial, responders (26%) were characterized by chromosomal instability, TP53 mutations, and proliferative cell‐cycle programs, whereas nonresponders showed metabolic and stromal reprogramming with TGF‐β‐driven ...
Eleonora Piumatti +3 more
wiley +1 more source
Trade union membership and work councils in West Germany [PDF]
The fraction of works councillors belonging to a trade union in Germany is much higher than union density among employees. If works councils represent the face of unions, union membership of employees should be related positively to the existence of ...
Goerke, Laszlo, Pannenberg, Markus
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Molecular Oncology, EarlyView.The cancer problem is increasing globally with projections up to the year 2050 showing unfavourable outcomes in terms of incidence and cancer‐related deaths. The main challenges are prevention, improved therapeutics resulting in increased cure rates and enhanced health‐related quality of life.
Ulrik Ringborg +43 more
wiley +1 more source
Socrates and Sozomen’s Church History in Comparative Perspective
Darulhadis İslami Araştırmalar Dergisi, 2022 Beginning in the 4th century with Eusebius of Caesarea and continued by writers such as Socrates, Sozomenus and Theodoretus, church historiography is very important in terms of historiography.
Bahadır İkican
doaj
Works Councils and Heterogeneous Firms [PDF]
Theoretical analyses of the effects of works councils show ambiguous results. Therefore an empirical investigation of the issue is inevitable. The results so far are mixed, frequently a positive effect on productivity, but a negative one on profits is ...
Simon Renaud
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The effects of works councils on overtime hours - a censored quantile regression approach [PDF]
, 2012 This study analyzes the impact of German codetermination rights on overtime hours. Using German personal data, our results show that the effects of works councils strongly depend on the contracted working time.
Gralla, Rafael +2 more
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Peroxidasin enables melanoma immune escape by inhibiting natural killer cell cytotoxicity
Molecular Oncology, EarlyView.Peroxidasin (PXDN) is secreted by melanoma cells and binds the NK cell receptor NKG2D, thereby suppressing NK cell activation and cytotoxicity. PXDN depletion restores NKG2D signaling and enables effective NK cell–mediated melanoma killing. These findings identify PXDN as a previously unrecognized immune evasion factor and a potential target to improve
Hsu‐Min Sung +17 more
wiley +1 more source
Обозрение психиатрии и медицинской психологии имени В.М. Бехтерева, 2018 The carried-out retrieval revealed 2326 theses in 14.01.06 (14.00.18) «Psychiatry». In 1992-2015 about 97±6 theses were presented annually to dissertation councils of Russia. Doctor’s degree works there were 16.9%, candidate - 81.3%.
V. I. Evdokimov +3 more
doaj
Molecular Oncology, EarlyView.Methods to improve antibody–drug conjugate (ADC) treatment durability in cancer therapy are needed. We utilized ADCs and immune‐stimulating antibody conjugates (ISACs), which are made from two non‐competitive antibodies, to enhance the entry of toxic payloads into cancer cells and deliver immunostimulatory agents into immune cells.
Tiexin Wang +3 more
wiley +1 more source
Socialiniai Tyrimai, 2019 The state governance model is established by Constitution. In the Constitution of the Republic of Lithuania, there is a separate section dedicated to local self-governance and its management, that shows not only the state’s recognition of local self ...
Karolis Kaklys
doaj +1 more source