Results 191 to 200 of about 3,347,747 (263)

Practical Barriers to Real-World Implementation of Artificial Intelligence-Driven CT-Derived Fractional Flow Reserve. [PDF]

Korean J Radiol
Kim MY, Jin KN, Choe YH.
europepmc   +1 more source

IMPDH inhibition enhances cytarabine efficacy in SAMHD1‐expressing leukaemia cells via guanine nucleotide depletion

Molecular Oncology, EarlyView.
Cytarabine is a key therapy for acute myeloid leukaemia (AML), but its efficacy is limited by the dNTPase SAMHD1, which hydrolyses its active metabolite. Screening nucleotide biosynthesis inhibitors revealed that IMPDH inhibitors selectively sensitise SAMHD1‐proficient AML cells to cytarabine.
Miriam Yagüe‐Capilla, Christopher Dirks, Caroline Eiden, Sonja K. Fesenmayer, Femke M. Hormann, Yolande Klootsema, Ingrid Lilienthal, Si Min Zhang, Nikolas Herold, Sean G. Rudd   +9 more
wiley   +1 more source

A framework for clinical validation of generative artificial intelligence therapeutics. [PDF]

World Psychiatry
Galatzer-Levy IR, Tomasev N, Rodriguez C, Torous J.   +3 more
europepmc   +1 more source

Keratin 19 as a prognostic marker and contributing factor of metastasis and chemoresistance in high‐grade serous ovarian cancer

Molecular Oncology, EarlyView.
Keratin 19 (KRT19) is overexpressed in high‐grade serous ovarian cancer with high levels of Kallikrein‐related peptidases (KLK) 4–7 and is associated with poor survival. In vivo analyses demonstrate that elevated KRT19 increases peritoneal tumour burden.
Sophia Bielesch, Isabel Vogel, Sina Nokodian, Johanna Moeller, Antonia Blechschmidt, Vicky Hecht, Vanessa Kuentzel, Katharina Thiedig, Melissa Schwab, Oliver Schilling, Holger Bronger, Marion Kiechle, Viktor Magdolen, Tobias Dreyer   +13 more
wiley   +1 more source

Letter to the Editor: Impact of the intensivist at the bedside - the case of rational use of benzodiazepines. [PDF]

World J Crit Care Med
Nedel W.
europepmc   +1 more source

Kojève's silence: science and the end of history. [PDF]

Cont Philos Rev
van Gemert T.
europepmc   +1 more source

The imperative to embed ethics in health research priority-setting. [PDF]

Bull World Health Organ
Millum J, Aguilera B, Bhaumik S, Galvagni E, Littler K, Munung NS, Pierson L, Pratt B.   +7 more
europepmc   +1 more source

Implementing precision psychiatry in psychosis. [PDF]

World Psychiatry
McGuire P.
europepmc   +1 more source