Results 31 to 40 of about 1,198,222 (315)

Innovative approach to monitor performance of integrated disease surveillance and response after the Ebola outbreak in Sierra Leone: lessons from the field

BMC Health Services Research, 2022
Background Supervision of healthcare workers improves performance if done in a supportive and objective manner. Regular supervision is a support function of Integrated Disease Surveillance and Response (IDSR) strategy and allows systematic monitoring of ...
Charles Njuguna, Mohamed Vandi, James Sylvester Squire, Joseph Sam Kanu, Wilson Gachari, Evans Liyosi, Jane Githuku, Alexander Chimbaru, Ian Njeru, Victor Caulker, Malimbo Mugagga, Stephen Sesay, Ali Ahmed Yahaya, Ambrose Talisuna, Zabulon Yoti, Ibrahima Socé Fall   +15 more
doaj   +1 more source

Infection Control Practices for Vascular Access Management in Hemodialysis: Results From a Nationwide Survey of Japanese National University Hospitals

Therapeutic Apheresis and Dialysis, EarlyView.
ABSTRACT Introduction Bloodstream infections due to repeated vascular access (VA) puncture and circuit connections remain major concerns in hemodialysis. Therefore, we examined current practices for glove, disinfectant, and personal protective equipment (PPE) use according to VA type in national university hospitals in Japan.
Aiko Yamada, Makoto Harada, Tadahiko Kikugawa, Takeshi Nakata, Koji Hashimoto, Tsuneo Konta, Yuji Kamijo   +6 more
wiley   +1 more source

Organoids in pediatric cancer research

FEBS Letters, EarlyView.
Organoid technology has revolutionized cancer research, yet its application in pediatric oncology remains limited. Recent advances have enabled the development of pediatric tumor organoids, offering new insights into disease biology, treatment response, and interactions with the tumor microenvironment.
Carla Ríos Arceo, Jarno Drost
wiley   +1 more source

Reciprocal control of viral infection and phosphoinositide dynamics

FEBS Letters, EarlyView.
Phosphoinositides, although scarce, regulate key cellular processes, including membrane dynamics and signaling. Viruses exploit these lipids to support their entry, replication, assembly, and egress. The central role of phosphoinositides in infection highlights phosphoinositide metabolism as a promising antiviral target.
Marie Déborah Bancilhon, Bruno Mesmin
wiley   +1 more source

Reforming the World Health Organization

JAMA, 2011
IN DECEMBER 2010, JACK CHOW, 1 THE FORMER WORLD Health Organization (WHO) assistant directorgeneral, asked, “Is the WHO becoming irrelevant?” A month later, the WHO’s executive board considered the agency’s future within global health governance. After a yearlong consultation with member states on its financing, Director-General Margaret Chan called ...
Sridhar, Devi, Gostin, Lawrence O.
openaire   +4 more sources

Protein pyrophosphorylation by inositol pyrophosphates — detection, function, and regulation

FEBS Letters, EarlyView.
Protein pyrophosphorylation is an unusual signaling mechanism that was discovered two decades ago. It can be driven by inositol pyrophosphate messengers and influences various cellular processes. Herein, we summarize the research progress and challenges of this field, covering pathways found to be regulated by this posttranslational modification as ...
Sarah Lampe, Tanmay Kumar Mohanty, Rashna Bhandari, Dorothea Fiedler   +3 more
wiley   +1 more source

Planning to improve global health: the next decade of tuberculosis control

Bulletin of the World Health Organization, 2007
The Global Plan to Stop TB 2006-2015 is a road map for policy-makers and managers of national programmes. It sets out the key actions needed to achieve the targets of the Millennium Development Goals relating to tuberculosis (TB): to halve the prevalence
Dermot Maher, Chris Dye, Katherine Floyd, Andrea Pantoja, Knut Lonnroth, Alasdair Reid, Eva Nathanson, Thad Pennas, Uli Fruth, Jane Cunningham, Heather Ignatius, Mario C Raviglione, Irene Koek, Marcos Espinal   +13 more
doaj  

A circulating vaccine-derived poliovirus type 2 outbreak in a chronic conflict setting: a descriptive epidemiological study in South Sudan – 2020 to 2021

BMC Infectious Diseases, 2023
Background In this study, we describe the epidemiological profile of an outbreak of the circulating Vaccine Derived Polio Virus type 2 in South Sudan from 2020 to 2021. Method We conducted a retrospective descriptive epidemiological study using data from
Ayesheshem Ademe Tegegne, Atem Nathan Anyuon, George Awzenio Legge, Melisachew Adane Ferede, Zingbondo Isaac, Kirbak Anthony Laku, Sibhatu Biadgilign, Ochan Taban David Kilo, Fabian Ndenzako, Ndoutabe Modjirom, Olushayo Oluseun Olu, Sylvester Maleghemi   +11 more
doaj   +1 more source

The (Glg)ABCs of cyanobacteria: modelling of glycogen synthesis and functional divergence of glycogen synthases in Synechocystis sp. PCC 6803

FEBS Letters, EarlyView.
We reconstituted Synechocystis glycogen synthesis in vitro from purified enzymes and showed that two GlgA isoenzymes produce glycogen with different architectures: GlgA1 yields denser, highly branched glycogen, whereas GlgA2 synthesizes longer, less‐branched chains.
Kenric Lee, Dimitrios Bekiari, Sofia Doello, Karl Forchhammer   +3 more
wiley   +1 more source

Organ‐specific redox imbalances in spinal muscular atrophy mice are partially rescued by SMN antisense oligonucleotides

FEBS Letters, EarlyView.
We identified a systemic, progressive loss of protein S‐glutathionylation—detected by nonreducing western blotting—alongside dysregulation of glutathione‐cycle enzymes in both neuronal and peripheral tissues of Taiwanese SMA mice. These alterations were partially rescued by SMN antisense oligonucleotide therapy, revealing persistent redox imbalance as ...
Sofia Vrettou, Brunhilde Wirth
wiley   +1 more source