Results 231 to 240 of about 686,123 (339)

Macrophage Zc3h12c Limits Tissue Inflammation and Injury via Alternative Splicing of Pre‐mRNA

open access: yesAdvanced Science, EarlyView.
This work defines the context‐dependent function of Zc3h12c in macrophages using the Tnfrsf11a‐Cre system. It reveals Zc3h12c's dual mechanism—regulating RNA degradation and alternative splicing—with STAT1 as a key target. The findings elucidate a novel post‐transcriptional pathway and identify STAT1 isoforms as potential therapeutic targets for kidney
Chenyu Li   +14 more
wiley   +1 more source

Engineering DNA Origami Captors for TGFβ1 Sequestration to Enhance Tumor Immune Modulation and Therapy

open access: yesAdvanced Science, EarlyView.
Programmable DNA framework captors effectively deplete circulatingtransforming growth factor‐β1 (TGFβ1) through fast systemic clearance and reshape the tumor immune microenvironment, alleviating immunosuppression to inhibit tumor progression. Abstract Efficient modulation of pivotal immune‐regulatory molecules to leverage the tumor microenvironment ...
Xiao Chen   +7 more
wiley   +1 more source

Engineered Anti‐Senescence Trachea With Post‐Transplanted Regenerative Homeostasis

open access: yesAdvanced Science, EarlyView.
Bioengineered trachea undergoes post‐transplanted senescence, which is found in this study for the first time. Hebe‐ET is designed with dual anti‐senescence strategies: fiber‐film scaffold in cartilage rings for close‐packed cell interaction, and quercetin‐loaded fibrous rings for immune modulation.
Ziyin Pan   +14 more
wiley   +1 more source

[Primary care and mental health: Lessons and challenges in the post-pandemic world]. [PDF]

open access: yesAten Primaria
Escobar-Segovia K   +2 more
europepmc   +1 more source

Hierarchically Engineered Flame‐Retardant Triboelectric Yarn Exhibiting Robust Mechanical Performance and Humidity‐Boosted Electrical Output for Firefighting Applications

open access: yesAdvanced Science, EarlyView.
Inspired by a high‐temperature‐resistant wire, a Super Intelligent Fireproof Yarn is developed through the technology of hierarchical textile assembly. This yarn exhibits high tensile strength, shear resistance, and excellent flame‐retardant performance, and achieves humidity‐enhanced triboelectric output, enabling it to meet the demands of extreme ...
Ying Sun   +9 more
wiley   +1 more source

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