Results 21 to 30 of about 177,955,801 (276)

O novo paradigma da violência The new paradigm of violence

open access: yesTempo Social, 1997
O autor procura redimensionar o conceito de violência dentro do atual estado de globalização mundial. Crise internacional, narcotráfico, derrocada do bloco socialista no leste europeu, políticas assistenciais de organismos internacionais, conceitos de ...
Michel Wieviorka
doaj   +1 more source

Environment Matters at the World Bank, 2009 Annual Review : Banking on Biodiversity [PDF]

open access: yes, 2010
This issue of environment matters celebrates the 2010 international year of biodiversity and describes some of the challenges and opportunities in protecting biodiversity for the benefit of humankind. From
World Bank
core   +1 more source

La música de tradición oral en los tiempos de la world music. ¿Es posible una protección legal más allá del derecho de autor?

open access: yesEl oído pensante, 2020
La propiedad intelectual, tal como ha sido definida por el derecho occidental, ha tendido a ignorar las especificidades y multiplicidades de la creación musical. Los mecanismos diseñados a partir de esta concepción, basados en la invariabilidad de los textos y en el aprovechamiento económico, han favorecido un sistema que permite el uso indiscriminado ...
openaire   +3 more sources

World Development Indicators 2010

open access: yes, 2010
The 1998 edition of world development indicators initiated a series of annual reports on progress toward the International development goals. In the foreword then, World Bank President James D. Wolfensohn recognized
World Bank
core   +1 more source

From junk to function — How weak selection in eukaryotes builds new parts and drives genomic complexity

open access: yesFEBS Letters, EarlyView.
How do genomes gain new functional parts? In eukaryotes, which tend to evolve under weak selection, much of the genome is junk. Palazzo and Qiu borrow the logic of Markov chains to show how non‐functional DNA becomes functional through the appearance of intermediate states, which arise due to epistasis, buffering, and biochemical messiness, allowing ...
Alexander F. Palazzo, Yi Qiu
wiley   +1 more source

The Shewanella oneidensis Fic enzyme SoFic targets the switch‐I region of EF‐Tu for AMPylation

open access: yesFEBS Letters, EarlyView.
Fic enzymes mediate diverse post‐translational modifications across all domains of life, including AMPylation. Prokaryotic EF‐Tu can be AMPylated and deAMPylated by the conserved Fic enzyme SoFic. Structural and biochemical approaches were used to characterize the effect of AMPylation on EF‐Tu, SoFic's enzymatic activities, and the enzyme‐target ...
Svenja Runge   +6 more
wiley   +1 more source

PAK1 activation drives divergent resistance mechanisms to aromatase inhibition and tamoxifen in a luminal: A breast cancer model

open access: yesMolecular Oncology, EarlyView.
Breast cancer remains a major cause of cancer death in women, frequently developing endocrine therapy resistance. This study demonstrates that upregulated p21‐activated kinase 1 (PAK1) activity drives resistance to tamoxifen and long‐term estrogen deprivation in ER+ breast cancer models.
Luisa Schwarzmüller   +10 more
wiley   +1 more source

Tanzania at the Turn of the Century : Background Papers and Statistics

open access: yes, 2002
This report is the successor to the Country Economic Memorandum for Tanzania prepared in 1996 (World Bank 1996). The 1996 memorandum focused on the challenge of reforms and paid particular attention to the
World Bank   +1 more
core   +1 more source

p190A/ARHGAP35 and p190B/ARHGAP5 proteins in endometrial cancer: a novel cancer‐relevant paralog interplay

open access: yesMolecular Oncology, EarlyView.
This study identifies ARHGAP5, in addition to the frequently mutated ARHGAP35, as significantly mutated in endometrial cancer. Mutations in both genes co‐occur and are associated with their correlated downregulation. Functional CRISPR studies show that both paralogs regulate similar pathways, including actin cytoskeleton organization.
Mathilde Pinault   +12 more
wiley   +1 more source

World Development Indicators 2005

open access: yes, 2005
Five years ago the Millennium Declaration recorded the commitment of the members of the United Nations to eliminate poverty and to build a secure and peaceful world conducive to human development.
World Bank
core   +1 more source

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