Results 91 to 100 of about 133,411 (262)
The history, genome and biology of NCTC 30: a non-pandemic Vibrio cholerae isolate from World War One. [PDF]
Proc Biol Sci, 2019 Dorman MJ +9 more
europepmc +1 more source
Design and analysis strategies for robust microbiome ageing research
FEBS Letters, EarlyView.The gut microbiome changes with age and associates with age‐related morbidity and mortality, establishing it as a potential biomarker and intervention target for ageing. Realising this potential requires methodological rigour, yet distinguishing biological signals from methodological artefacts remains challenging across cohorts. This review provides an
Mark Olenik +5 more
wiley +1 more source
From the Trenches to the Cosmos: The Great War Testimonies of Teilhard de Chardin and Ernst Jünger [PDF]
Close Encounters in War JournalThe First World War’s unprecedented and all-encompassing nature has led to reevaluating how war is understood, especially regarding its cosmic significance.
Massimo Lollini
doaj
FEBS Letters, EarlyView.CT10 regulator of kinase (CRK) and CRK‐Like (CRKL) are signaling adaptors driving cell adhesion, motility, differentiation, and proliferation. SH2‐domain containing (SH) proteins are enriched in YXXP motifs which when phosphorylated create preferred binding sites for CRK family SH2 domains.
Phoebe M. Cousens +8 more
wiley +1 more source
Prenatal loss of father during World War One is predictive of a reduced lifespan in adulthood. [PDF]
Proc Natl Acad Sci U S A, 2017 Todd N, Valleron AJ, Bougnères P.
europepmc +1 more source
FEBS Letters, EarlyView.Protein aggregates threaten proteostasis and cell health. In human cells, Hsp70–J‐domain protein‐based disaggregases remove aggregates, but how they assemble remains unclear. Our biochemical findings show that DNAJA2‐ and DNAJB1‐containing disaggregase scaffolds enhance luciferase aggregate targeting, and that Hsp70 recruitment by both J‐domain ...
Anna Szlachcic, Nadinath B. Nillegoda
wiley +1 more source
A Basque Media War: Who is Ireland’s Friend, Who is Ireland’s Enemy? The Easter Rising’s Influence, Context and Development in the Basque Country [PDF]
Estudios IrlandesesThis paper examines the inner debate in Basque nationalism resulting from the Easter Rising between 1916 and 1918. Basque nationalists firmly believed that the Irish Revolution would affect the British war effort, the outcome of the Great War and hence ...
Alejandro Pulido Azpíroz
doaj
Reconstructing enzyme evolution by protein engineering
FEBS Letters, EarlyView.Natural enzyme evolution can be retraced by protein engineering methods such as directed evolution, rational design, and ancestral sequence reconstruction. These approaches reveal how enzymes emerged from ligand‐binding scaffolds, developed varying substrate preferences, formed oligomeric complexes, adapted to environmental changes, and evolved novel ...
Lukas Drexler +2 more
wiley +1 more source
“Si va avanti, ma Trieste non si prende mai!” L’irredentismo al battesimo del fuoco
Zibaldone: Estudios Italianos, 2018 Tra i molti concetti seminati dalla propaganda prebellica per indirizzare la volontà popolare poi sconfessati dalla realtà di guerra, l’irredentismo costituisce sicuramente un singolare caso di studio: radicatosi profondamente nel tessuto retorico della ...
Tancredi Artico
doaj
FEBS Letters, EarlyView.The process of internalization of the Shiga toxin A subunit via formation of a complex with the Shiga toxin B subunit, which specifically binds to the Gb3 receptor. The peptide is designed to act as a carrier of drugs into cancer cells. Here, we explored the potential of peptides derived from the catalytic A subunit of Shiga toxin (STxA) to be drug ...
Giulia Opassi +6 more
wiley +1 more source