Results 101 to 110 of about 133,411 (262)
Investigating transcription factor dynamics in health and disease using FRAP
FEBS Letters, EarlyView.FRAP analysis of GFP‐tagged transcription factors reveals how molecular mobility and target engagement change in response to drug treatment. By combining live‐cell imaging, quantitative model fitting, and statistical analysis, this approach uncovers transcription factor dynamics linked to disease mechanisms, providing a powerful framework for ...
Kannan Govindaraj +3 more
wiley +1 more source
Global Origins of World War One. Part Two: A Chain of Revolutionary Events Across the World Island
Historia Actual On-Line, 2009 El camino a la Gran Guerra se inició con los alineamientos formados a causa de la contienda por las concesiones en el Oriente Lejano. La crisis mundial de 1904-1905 encuadró los alineamientos.
Anthony D'Agostino
doaj
Conserved binding mode but diverse interfaces of MreC‐PBP2 interactions
FEBS Letters, EarlyView.The crystal structure of abMreC reveals a conserved two β‐barrel architecture and provides structural insights into its role within the bacterial elongasome. The abMreC–abPBP2 complex model identifies the molecular basis of MreC‐mediated PBP2 recognition, contributing to the regulation of peptidoglycan synthesis.
Hyunseok Jang +4 more
wiley +1 more source
FEBS Letters, EarlyView.The mycobacterial CIII‐CIV respiratory supercomplex is an obligate assembly, encompassing several subunits of unknown functions. We have characterized the intracellular subunit AscF, and show that it is unlikely to be a sensor for metals or nucleotides, but is required for growth on nonfermentable energy sources, and likely works as an adapter for ...
Eni Rile +8 more
wiley +1 more source
Russians, Jews, and Poles: Russification and Antisemitism 1881-1914
Quest. Issues in Contemporary Jewish History, 2012 Relations between Poles and Jews deteriorated significantly in the three decades leading up to World War I. Many reasons for this phenomenon can be given, for example: economic competition, a general atmosphere of acute nationalism, increased migration,
Theodor R. Weeks
doaj
World War One: A War of Nerves
World War One: A War of Nerves21 世紀に入って勃発した戦争やテロ活動は、社会へ与えた衝撃や現代社会への心理的影響力によってメディアの必然的関心となっている。一方、第一次世界大戦は、一般市民は戦争から隔離され、遠く離れた戦線で行われた戦争とは直接的関与がないままに遂行されたこともあり、紳士的かつ良心的戦争であるという認識がある。そのため一般的に軽視されがちである。しかし戦史上未曾有の戦線での大量殺戮、さらに第一次大戦がもたらした社会的影響は見逃せないものであり、近代ヨーロッパ社会の根幹を揺るがした戦争として注目に値するのである。
openaire
Identification of the plant mitochondrial OrfX protein: A mass spectrometry approach
FEBS Letters, EarlyView.The mitochondrial genome of plants contains an open reading frame, orfx, which encodes a rare protein that has so far escaped mass spectrometric detection. The protein resembles the c‐subunit of bacterial twin‐arginine‐motif‐dependent protein translocases (TatC).
Matthias Döring +3 more
wiley +1 more source
The role of miR‐335‐5p in the redifferentiation of BRAF p.V600E thyroid cancers
Molecular Oncology, EarlyView.The BRAF p.V600E mutation promotes thyroid cancer dedifferentiation and radioiodine resistance. Using a network approach, we identified miR‐335‐5p as a key regulator of BRAF‐mutated thyroid tumors. Restoring miR‐335‐5p increased thyroid‐specific gene expression and iodine uptake in cells and organoids.
Valeria Pecce +11 more
wiley +1 more source
Tumour–host interactions in Drosophila: mechanisms in the tumour micro‐ and macroenvironment
Molecular Oncology, EarlyView.This review examines how tumour–host crosstalk takes place at multiple levels of biological organisation, from local cell competition and immune crosstalk to organism‐wide metabolic and physiological collapse. Here, we integrate findings from Drosophila melanogaster studies that reveal conserved mechanisms through which tumours hijack host systems to ...
José Teles‐Reis, Tor Erik Rusten
wiley +1 more source
Molecular Oncology, EarlyView.Dimethyl fumarate (DMF) reduces growth of HPV‐positive cervical cancer spheroids and induces ferroptosis in cervical cancer cells via blocking SLC7A11/Glutathione (GSH) axis. Combination of subcytotoxic doses of DMF and cisplatin (CDDP) further suppresses spheroid growth and drives cell death in 2D culture models.
Carolina Punziano +6 more
wiley +1 more source