Results 91 to 100 of about 1,578,031 (314)

Detection of circulating tumor DNA in colorectal cancer patients using a methylation‐specific droplet digital PCR multiplex

Molecular Oncology, EarlyView.
We developed a cost‐effective methylation‐specific droplet digital PCR multiplex assay containing tissue‐conserved and tumor‐specific methylation markers. The assay can detect circulating tumor DNA with high accuracy in patients with localized and metastatic colorectal cancer.
Luisa Matos do Canto, Louise Raunkilde, Jan Lindebjerg, Mads Malik Aagaard, Christina Therkildsen, Jakob Kleif, Lars Henrik Jensen, Torben Frøstrup Hansen, Rikke Fredslund Andersen   +8 more
wiley   +1 more source

Multifunctional hydrogel targeting senescence to accelerate diabetic wound healing through promoting angiogenesis

Journal of Nanobiotechnology
Diabetic wound healing remains a significant clinical challenge because of hyperglycaemia-induced cellular senescence, impaired angiogenesis, and chronic inflammation. To address these issues, we developed a multifunctional hydrogel (GelMA/PNS/Alg@IGF-1)
Hao Yang, Yongfei Chen, Yanchao Rong, Yuxi Zhou, Shuting Li, Xiaohui Li, Honglin Wu, Dongming Lv, Xiaoling Cao, Peng Wang, Jiayuan Zhu, Bing Tang, Zhicheng Hu   +12 more
doaj   +1 more source

A Pilot Study for Enhancing Postpartum Discharge Instructions for Incision Care: Assessment of Comprehension [PDF]

, 2017
Literacy and Health Care • 14.5% of United States is illiterate 1 • Reading level of most medical forms is 10th grade 2 Improving Outcomes with a Visual Aid • Cesarean Surgical Site Infection (SSI) rate is 5% 3 • A patient with a SSI can be 2 times as
Baxter, MD, MSCP, Jason K., Cohen, BS, Sarah, Lawrence, BS, Rebecca, McCurdy, MD, Rebekah Jo   +3 more
core   +1 more source

Perspectives in educating molecular pathologists on liquid biopsy: Toward integrative, equitable, and decentralized precision oncology

Molecular Oncology, EarlyView.
Liquid biopsy enables minimally invasive, real‐time molecular profiling through analysis of circulating biomarkers in biological fluids. This Perspective highlights the importance of training pathologists through integrative educational programs, such as the European Masters in Molecular Pathology, to ensure effective and equitable implementation of ...
Marius Ilié, Umberto Malapelle, Catherine Alix‐Panabières, Claus Lindbjerg Andersen, Sandra Chlebowski, Vivien Lake, Caroline Lacoux, Virginie Lespinet‐Fabre, Olivier Bordone, Simon Heeke, Christophe Bontoux, Ellen Heitzer, Klaus Pantel, Paul Hofman   +13 more
wiley   +1 more source

CHRONIC WOUNDS

Surgical Clinics of North America, 1997
Skin ulcers are the most common chronic wounds. Current management principles and theories of causation of the most common ulcers--pressure, diabetic, and venous--are described. Issues related to occlusive dressings, compression dressings, topical antimicrobials, debridement, growth factors, grafting, and bioengineered tissue therapy are discussed ...
W H, Eaglstein, V, Falanga
openaire   +2 more sources

Transcriptional network analysis of PTEN‐protein‐deficient prostate tumors reveals robust stromal reprogramming and signs of senescent paracrine communication

Molecular Oncology, EarlyView.
Combining PTEN protein assessment and transcriptomic profiling of prostate tumors, we uncovered a network enriched in senescence and extracellular matrix (ECM) programs associated with PTEN loss and conserved in a mouse model. We show that PTEN‐deficient cells trigger paracrine remodeling of the surrounding stroma and this information could help ...
Ivana Rondon‐Lorefice, Jose I. Lopez, Aitziber Ugalde‐Olano, Maite Zufiaurre, Ianire Astobiza, Natalia Martin‐Martin, Laura Bozal‐Basterra, Saioa Garcia‐Longarte, Amaia Zabala‐Letona, Sofia Rey, Aida Santos‐Martin, Miguel Unda, Ana Loizaga‐Iriarte, Mariona Graupera, Paolo Nuciforo, Arkaitz Carracedo, Isabel Mendizabal   +16 more
wiley   +1 more source

Research on the Role of Autophagy in Vascular Endothelial Cells in the Healing of Chronic Refractory Wounds

Biologics: Targets & Therapy
Lao Riling,1 Fan Kunyue,1 Gan Liyan,2 Wang Yaya,1 Ni Baoling,1 Li Jiehui3 1Department of Wound Repair Surgery,Guangxi Province Hospital, Guangxi University of Traditional Chinese Medicine, Nan Ning, Guang Xi, People’s Republic of China; 2Department of ...
Riling L, Kunyue F, Liyan G, Yaya W, Baoling N, Jiehui L   +5 more
doaj  

A fibrocontractive mechanochemical model of dermal wound\ud closure incorporating realistic growth factor kinetics [PDF]

, 2011
Fibroblasts and their activated phenotype, myofibroblasts, are the primary cell types involved in the contraction associated with dermal wound healing.
Hall, C. L., Maini, P. K., McCue, S. W., McElwain, D. L. S., Murphy, K. E.   +4 more
core  

Marrow-derived stromal cell delivery on fibrin microbeads can correct radiation-induced wound-healing deficits. [PDF]

, 2013
Skin that is exposed to radiation has an impaired ability to heal wounds. This is especially true for whole-body irradiation, where even moderate nonlethal doses can result in wound-healing deficits.
Gaberman, Elena, Gorodetsky, Raphael, Levdansky, Lilia, Mackenzie, Natalia C, McBride, William H, Micewicz, Ewa D, Xie, Michael W   +6 more
core   +1 more source

Potential therapeutic targeting of BKCa channels in glioblastoma treatment

Molecular Oncology, EarlyView.
This review summarizes current insights into the role of BKCa and mitoBKCa channels in glioblastoma biology, their potential classification as oncochannels, and the emerging pharmacological strategies targeting these channels, emphasizing the translational challenges in developing BKCa‐directed therapies for glioblastoma treatment.
Kamila Maliszewska‐Olejniczak, Karolina Pytlak, Sandra Jaworowska, Bogusz Kulawiak, Piotr Bednarczyk   +4 more
wiley   +1 more source