Results 111 to 120 of about 350 (182)

Synergistic Interaction Between MALAT1/miR‐30b‐5p/BAFF Axis and Inflammatory Cytokines Underlies Rituximab‐Refractory NMOSD

CNS Neuroscience &Therapeutics, Volume 32, Issue 6, June 2026.
The MALAT1/miR‐30b‐5p/BAFF axis is activated in monocytes during NMOSD onset and relapse. The MALAT1/miR‐30b‐5p/BAFF axis is activated in monocytes, thereby facilitating the release of BAFF and inflammatory cytokines (including IL‐1, IL‐6, IL‐8, and TNF‐α).
Meiqun Deng, Keyi Zeng, Wei Chen, Jing Chen, Xiaoting Lin, Lei Chen, Yuxin Yao, Hanfei Chen, Aiyu Lin   +8 more
wiley   +1 more source

A RiboCancer cell line panel reveals that CLL‐associated Rps15 mutations translationally rewire transcription through codon‐specific tRNA accommodation defects

HemaSphere, Volume 10, Issue 6, June 2026.
Abstract Recurrent point mutations in ribosomal proteins (RPs) RPL10 and RPS15 are found in T‐cell acute lymphoblastic leukemia (T‐ALL) and chronic lymphocytic leukemia (CLL), respectively. Furthermore, deletions of RPL5, RPL11, and RPL22 are frequent in hematologic diseases such as Diamond Blackfan Anemia, T‐ALL, multiple myeloma, and in a variety of ...
Anaïs Astier, Marino Caruso, Stijn Vereecke, Paulo E. Santo, Coralie Capron, Carine Froment, Dana Rinaldi, David Cabrerizo Granados, Marine Leclercq, Jonathan Royaert, Jelle Verbeeck, Naomy Pasau, Laura Plassart, Daniele Pepe, Steven Verbruggen, Hermes Paraqindes, Simon Lebaron, Virginie Marcel, Sébastien Durand, Clément Chapat, Gerben Menschaert, Pierre Close, Francesca Rapino, Frédéric Catez, Julien Marcoux, Célia Plisson‐Chastang, Kim De Keersmaecker   +26 more
wiley   +1 more source

Multifaceted Role of Extracellular Vesicles: Intercellular Messengers to Therapeutic Applications: A Narrative Review

Health Science Reports, Volume 9, Issue 6, June 2026.
ABSTRACT Background and Aims Extracellular vesicles (EVs) are nanoscale carriers, including exosomes, microvesicles, and apoptotic bodies, that mediate intercellular communication by transporting proteins, nucleic acids, lipids, and metabolites. They regulate immunity, tissue repair, and cell differentiation.
Kajal Kamra, Satya Kumar Lalam, Shefali Srivastava, Madan Kumar Arumugam, Lokesh Kumar Boopathy, Simran Takkar, Zhiqiu Xia, Sabarinath Peruvemba Subramanian   +7 more
wiley   +1 more source

Cannabidiol Protects Against 1‐Methyl‐4‐Phenylpyridinium and Manganese‐Induced Neurotoxicity via Nod‐Like Receptor Protein 3 Inflammasome Suppression

Journal of Biochemical and Molecular Toxicology, Volume 40, Issue 6, June 2026.
CBD oil exhibits neuroprotective effects in Parkinson's disease models by inhibiting NLRP3 inflammasome activation. It preserves dopamine levels and reduces α‐synuclein accumulation, suggesting its potential as a therapeutic strategy against neuroinflammation and neurodegeneration.
Göksun Demirel, Anıl Yirün, Deniz Arca Çakir, Hüseyin Özkan, Berfu Şura Güneş, Selen Selvi, Yeter EROL. Öztürk, Pınar Erkekoğlu   +7 more
wiley   +1 more source

Impact of Isolation Techniques on the Content of Small Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT An important topic of discussion amongst the extracellular vesicle (EV) research field is which genetic materials are considered true constituents of EV cargo. What were once regarded as non‐EV components have now evolved to be potentially essential to EV composition, serving as key mediators in communication.
Yue Su, Kekoolani S. Visan, Sarah Voss, Marta Prieto‐Vila, Juntaro Matsuzaki, Jason Ying Kuen Chan, Judy Wai Ping Yam, Andreas Möller   +7 more
wiley   +1 more source

Status Epilepticus Alters the Function of Brain‐Derived Extracellular Vesicles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Epilepsy is a neurological disorder characterised by recurrent spontaneous seizures. Approximately 30% of patients are unable to achieve adequate seizure control with available medications, highlighting the need to better understand disease mechanisms and develop improved treatments.
Samantha L. Reed, Yilin Wang, Yangping Li, Guoku Hu, Jingjing Yang, Bing Yao, Andrew Escayg   +6 more
wiley   +1 more source

Engineered Pericyte‐Targeted Extracellular Vesicles Protect Against Hypoperfusion‐Induced Cognitive Impairment and Vascular Demyelination

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
Schematic illustration on a therapeutic strategy wherein engineered extracellular vesicles (EVs) are delivered intranasally and specifically target pericytes. In a model of chronic cerebral hypoperfusion (BCAS), this targeted approach preserves cerebral blood flow, reinforces blood‐brain barrier (BBB) integrity, stabilizes the neurovascular unit (NVU),
Weiwei Shen, Weishi Liu, Min Guo, Tongyao You, Yingzhe Wang, Tiansiyu Wen, Suzhen Liang, Xiaodi Xie, Yanfeng Jiang, Qiang Dong, Jin‐Tai Yu, Mei Cui   +11 more
wiley   +1 more source

Targeted Delivery of mRNA to the Heart via Extracellular Vesicles or Lipid Nanoparticles

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Efficient and specific delivery of mRNA to target tissues is critical for maximising therapeutic benefits while minimising off‐target effects and systemic toxicity. Systemic administration of mRNA using lipid nanoparticles (LNPs) or extracellular vesicles (EVs) typically leads to predominant accumulation in the liver.
Muhammad Nawaz, Benyapa Tangruksa, Sepideh Heydarkhan‐Hagvall, Franziska Kohl, Hernán González‐King Garibotti, Yujia Jing, Zahra Payandeh, Azadeh Reyahi, Karin Jennbacken, John Wiseman, Leif Hultin, Lennart Lindfors, Jane Synnergren, Hadi Valadi   +13 more
wiley   +1 more source

Characterizing the Fate of Anti‐CS1 Nanobody Displaying Extracellular Vesicles in Multiple Myeloma

Journal of Extracellular Vesicles, Volume 15, Issue 6, June 2026.
ABSTRACT Extracellular vesicles (EVs) are promising delivery vehicles capable of transporting therapeutic agents across biological barriers. However, native EVs primarily accumulate in liver, spleen and lungs, limiting targeted delivery to disease sites.
Michiel De Coster, Lukas Hyka, Sophie De Cock, Sofie Meeussen, Zuowei Wang, Chenggong Tu, Sophie Hernot, Nick Devoogdt, Guido David, Kim De Veirman, Karin Vanderkerken, Eline Menu, Pascale Zimmermann, Elke De Bruyne   +13 more
wiley   +1 more source

Extracellular Vesicle‐Associated IL4 Displays Enhanced Anti‐Inflammatory Properties in Microglial Cells

Journal of Extracellular Biology, Volume 5, Issue 6, June 2026.
ABSTRACT Neuroinflammation and neurodegeneration are strictly related phenomena, characterized by dysregulation of microglia, central nervous system (CNS) resident immune cells. Interleukin‐4 (IL4) has shown beneficial abilities to re‐establish microglial homeostasis in experimental models of CNS traumatic injury, stroke and multiple sclerosis, but its
Giulia Marostica, Chiara Frigè, Annamaria Finardi, Alessandra Mandelli, Susanna Manenti, Stella Siciliani, Paola Podini, Ivan De Curtis, Luca Muzio, Elena Rossi, Paola de Candia, Roberto Furlan   +11 more
wiley   +1 more source