Results 201 to 210 of about 68,858 (291)

Neonatal Wet Gangrene With Early Auto-Amputation in a Resource-Limited Setting With Incomplete Etiologic Workup: A Case Report. [PDF]

Clin Case Rep
Feyisa MT, Eshetu B, Dibisa T, Gshaw M, Tolera B, Birara ED, Lamessa A, Woyimo TG.   +7 more
europepmc   +1 more source

A New Paradigm: 46 Structural Cell Types Function as Environment‐Supporting Innate Immune Cells, With Endothelial and Vascular Smooth Muscle Cells as Key Prototypes

iNew Medicine, EarlyView.
ABSTRACT The scope, organization, and biological significance of innate immune functions across structural cell types remain poorly defined. To address these fundamental knowledge gaps, we analyzed experimental data of transcriptomes generated by our group and others.
Juanjuan Liu, Gayani K. Nanayakkara, Yifan Lu, Fatma Saaoud, Keman Xu, Ying Shao, Bo Yuan, Shih‐Yu Hung, Haiyan Xiang, Xianwei Wang, Sadia Mohsin, Sheng Wu, Xiaolei Liu, Juncheng Wei, Zhengjie Zhou, Beata Kosmider, Mingui Fu, Laisel Martinez, Roberto Vazquez‐Padron, Wenhui Hu, Shuping Ge, Hong Wang, Xiaofeng Yang   +22 more
wiley   +1 more source

Diabetes and Diabetic Neuropathy Significantly Increase Short- and Long-Term Complications Following Single-Level Posterolateral Lumbar Fusion: A Propensity- Matched Cohort Study. [PDF]

Orthop Rev (Pavia)
Hilo AK, Haj Hamad Y, Jawich B, Forbes T, Harhash T, Mohammad H, Elnaggar A, Almaat A, Alqasmi H, Chu Y, Vaidya R.   +10 more
europepmc   +1 more source

Targeting Renal IGFBP7 With Tetrahedral Framework Nucleic Acid‐Delivered siRNA Alleviates Acute Kidney Injury

iNew Medicine, EarlyView.
A tFNA‐based siRNA delivery system targeting IGFBP7 effectively silences IGFBP7 expression and attenuates renal dysfunction, tubular injury, and cell death in both septic (CLP) and ischemic (I/R) murine models of acute kidney injury. ABSTRACT Objective Acute kidney injury (AKI) is a common and serious clinical condition, yet effective targeted ...
Shao‐qi Wu, Ying‐ying Gao, Meng‐yi Jia, Yu‐Hao Liu, Qian Zhou, Dong Liu, Yu Ren, Yu‐jie Liu, Feng‐he Li, Ya‐ru Yang, Jie Wang, Jia‐gen Wen   +11 more
wiley   +1 more source

Physiology-driven reversible dynamic synthetic tissue model for responsive moulage in infected wound training. [PDF]

PLoS One
Gong AT, DeSchmidt AM, Baird AJ, Gonzaga JG, Yau SO, Toepfer RJ, Zhang J, Parsey CJ, Leuschke R, Norfleet JE, Sweet RM.   +10 more
europepmc   +1 more source

Metrnl: A Novel Therapeutic Target in Atherosclerosis

iNew Medicine, EarlyView.
ABSTRACT Atherosclerosis is a chronic inflammatory vascular disease and the main pathological basis of cardiovascular and cerebrovascular events. Exploration of endogenous protective factors in the disease is beneficial for the establishment of new therapeutic strategies.
Pin Wang, Dao‐Xin Wang, Chao‐Yu Miao
wiley   +1 more source

Calciphylaxis as a Rare Complication Associated with Pemigatinib Treatment-A Case Report. [PDF]

Curr Oncol
Čular K, Hamzić DT, Smiljanić Tomičević L, Buzina DŠ, Bradamante M, Simetić L, Bilić I, Belev B.   +7 more
europepmc   +1 more source

Metrnβ drives sepsis immunosuppression via macrophage reprogramming: A novel prognostic biomarker and therapeutic target

Interdisciplinary Medicine, EarlyView.
Metrnβ serves as a novel prognostic biomarker for sepsis and that targeted blockade of the Metrnβ‐c‐Kit axis represents a promising therapeutic strategy for sepsis. Abstract Sepsis is a heterogeneous syndrome critically driven by immunosuppression, yet lacking personalized prognostic markers and therapeutic targets. Here, we provide evidence to support
Xiao Li, Ai Chen, Chen Zhang, Meihong Da, Yonghui Liu, Zhi He, Chenyan Yuan, Shuo Ma, Yuming Yao, Dawen Chen, Meiling Zhou, Zhixin Song, Wenjing Lu, Chun‐Kwok Wong, Guoqiu Wu, Xun Gao   +15 more
wiley   +1 more source

Comparison of Acute Physiology and Chronic Health Evaluation (APACHE) II, Physiological and Operative Severity Score for the Enumeration of Mortality and Morbidity (POSSUM), and Surgical Apgar Score in Patients Undergoing Emergency Laparotomy. [PDF]

Cureus
Marahanumaiah S, Reddy PV, Jagannath K, Galani N, Suresh N.   +4 more
europepmc   +1 more source

Single‐Cell Profiling Identifies CLEC5A+ Macrophages as Key Drivers of Thoracic Aortic Aneurysm Via CCL5‐Mediated M1 Polarization

Journal of Clinical Laboratory Analysis, EarlyView.
Thoracic aortic aneurysm (TAA) is a life‐threatening cardiovascular disease with limited therapeutic options. Through single‐cell RNA sequencing of aortic tissues from healthy individuals and TAA patients (105,541 cells), we identified CLEC5A+macrophages as the predominant pathogenic cell population exhibiting the highest M1 polarization score. Machine
Xiangyu Li, Chunguang Guo, Mingyao Luo, Chang Shu   +3 more
wiley   +1 more source