Results 211 to 220 of about 350,235 (287)

Unraveling 4‐Phenylbutyrate's Therapeutic Role in SLC6A1 Disorders: Pharmacochaperoning Over HDAC Inhibition

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Variants in SLC6A1, encoding the GABA transporter 1 (GAT‐1), cause epilepsy, autism spectrum disorder, and developmental delay via loss of GABA uptake, impaired trafficking, and ER retention. We previously found that 4‐Phenylbutyrate (PBA), an FDA‐approved drug, restores GABA uptake and reduces seizures in SLC6A1‐related disorders ...
Melissa B. DeLeeuw, Karishma Randhave, Ekta Anand, Ziang (Debbie) Song, Wangzhen Shen, Jing‐Qiong Kang   +5 more
wiley   +1 more source

Regenerative Performance and Structural Persistence of Silk Fibroin Matrices in Human Infected and Non-Infected Ex Vivo Wounds. [PDF]

Biomimetics (Basel)
Liegenfeld SC, Straub NP, Krueger N, Dittmer M, Delle Coste A, Strenge JT, Geissen M, Rhode SC, Streit WR, Smeets R, Stuermer EK.   +10 more
europepmc   +1 more source

Plasma EV Proteomics Identifies ECM Remodeling and Inflammatory Proteins LUM and C7 as Candidate Biomarkers in FSHD

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Facioscapulohumeral muscular dystrophy (FSHD) is one of the most debilitating and common muscular dystrophies. Despite its severity, no approved therapy exists for FSHD patients. However, several therapeutic candidates are currently under development, and some have recently entered clinical trials, marking the need for reliable ...
Mustafa Bilal Bayazit, Chiranth K. Nagaraj, Jackson S. Newell, Kim Truc Nguyen, Xilal Y. Rima, Jacob Doon‐Ralls, Eduardo Reátegui, Jeffrey M. Statland, Rabi Tawil, Kevin M. Flanigan, Scott Q. Harper, Nizar Y. Saad   +11 more
wiley   +1 more source

Transcriptomic Profiling of Diabetic Porcine Wound Healing Model Identifies Key Metabolic, Inflammatory, and Oxidative Stress Pathways. [PDF]

Wound Repair Regen
McCune JT, Bezold MG, Davidson JM, Serezani CH, Cook RS, Duvall CL.   +5 more
europepmc   +1 more source

A Two‐Stage Questionnaire and Actigraphy Screening for iRBD in a Multicenter Retrospective Cohort

Annals of Clinical and Translational Neurology, EarlyView.
ABSTRACT Objective Isolated rapid‐eye‐movement sleep behavior disorder is a prodromal marker of synucleinopathies. However, most cases remain undiagnosed due to the insufficient predictive value of questionnaires and limited access to confirmatory video‐polysomnography. We assessed a two‐stage screening strategy combining a brief questionnaire on rapid‐
Caleb A. Massimi, Giorgio Ricciardiello Mejia, Andre Metzger, Kang Hyun Ryu, Salonee Marwaha, Eva Grzegorczyk, Li Zhou, Eliana Jacobs, Boris Gilyadov, Claudia Kunney, Liqhwa Ncube, Ankit Parekh, Emmanuel Mignot, Fanny M. Elahi, Joseph Winer, Kathleen Poston, Andreas Brink‐Kjaer, Emmanuel H. During   +17 more
wiley   +1 more source

Hyperbaric Oxygen Therapy for Diabetic Lower-Limb Wounds in the Caribbean: A Retrospective Cohort Study. [PDF]

Int Wound J
Chingan Martino V, Pusel M, Bouamama D, Gibert D, Cheret A.   +4 more
europepmc   +1 more source

Fatal Self-Inflicted Chop Wound by a Supari Cutter (Sudi): A Rare Case With Forensic Analysis of Wound Patterns and Weapon Biomechanics. [PDF]

Cureus
G VK, Modi AM.
europepmc   +1 more source

Beyond the scalpel: forensic patterns, epistemic limits, and the medico-legal classification of femicide. [PDF]

Clinics (Sao Paulo)
Miziara CSMG, Miziara ID.
europepmc   +1 more source

Sulfated Polysaccharides in Wound Healing: From Bioactive Materials Design to Regenerative Therapeutics. [PDF]

Int J Nanomedicine
Hu G, Li L, Ouyang R, Ke X, Huang S, Yang P, Huang C.   +6 more
europepmc   +1 more source

Exosomes orchestrate immune homeostasis in acute ischemia-reperfusion flap injury and chronic wounds: the TLR4/NF-κB-STAT3 R-ratio balance decision model, engineering optimization and translational clinical strategy. [PDF]

Front Immunol
Yue Q, Chen J, Liu L, Liu H, Zeng X.
europepmc   +1 more source