Results 81 to 90 of about 656,119 (315)

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source

Plant-Based Films and Hydrogels for Wound Healing

Microorganisms
Skin is constantly exposed to injury and infectious agents that can compromise its structural integrity and cause wounds. When this occurs, microorganisms from the skin microbiota and external bacteria and fungi can penetrate the wound and cause an ...
Ana I. Lopes, Maria M. Pintado, Freni K. Tavaria   +2 more
doaj   +1 more source

The newfound relationship between extrachromosomal DNAs and excised signal circles

FEBS Letters, EarlyView.
Extrachromosomal DNAs (ecDNAs) contribute to the progression of many human cancers. In addition, circular DNA by‐products of V(D)J recombination, excised signal circles (ESCs), have roles in cancer progression but have largely been overlooked. In this Review, we explore the roles of ecDNAs and ESCs in cancer development, and highlight why these ...
Dylan Casey, Zeqian Gao, Joan Boyes
wiley   +1 more source

Agent-based computational modeling of wounded epithelial cell monolayers [PDF]

, 2004
Computational modeling of biological systems, or ‘in silico biology’ is an emerging tool for understanding structure and order in biological tissues. Computational models of the behavior of epithelial cells in monolayer cell culture have been developed ...
Hill, G., Smallwood, R.H., Southgate, J., Walker, D.C., Wood, S.M.   +4 more
core   +1 more source

Paraneoplastic Lupus Nephritis in a Child With Neuroblastoma Recurrence

Pediatric Blood &Cancer, EarlyView.
Gabriele Mortari, Caterina Costagliola, Marta Nebiolo, Francesca Parisi, Martina Morini, Katia Mazzocco, Gabriele Gaggero, Stefano Volpi, Stefania Sorrentino, Virginia Livellara   +9 more
wiley   +1 more source

Conserved structural motifs in PAS, LOV, and CRY proteins regulate circadian rhythms and are therapeutic targets

FEBS Letters, EarlyView.
Cryptochrome and PAS/LOV proteins play intricate roles in circadian clocks where they act as both sensors and mediators of protein–protein interactions. Their ubiquitous presence in signaling networks has positioned them as targets for small‐molecule therapeutics. This review provides a structural introduction to these protein families.
Eric D. Brinckman, Anna E. Lester, Brian D. Zoltowski   +2 more
wiley   +1 more source

Chronic Wounds: The Persistent Infection Problem [PDF]

, 2013
Chronic wounds heal poorly and can have a huge impact on a sufferer’s life. They are caused by a number of factors, one of which is the presence of persistent infections.
Davis, NG
core  

Inhibiting stearoyl‐CoA desaturase suppresses bone metastatic prostate cancer by modulating cellular stress, mTOR signaling, and DNA damage response

FEBS Letters, EarlyView.
Bone metastasis in prostate cancer (PCa) patients is a clinical hurdle due to the poor understanding of the supportive bone microenvironment. Here, we identify stearoyl‐CoA desaturase (SCD) as a tumor‐promoting enzyme and potential therapeutic target in bone metastatic PCa.
Alexis Wilson, Mackenzie K Herroon, Shane Mecca, Laimar C Garmo, Jacob Lindquist, Shrila Rajendran, Steve M. Patrick, Izabela Podgorski   +7 more
wiley   +1 more source

Effects of Electrical Stimulation on Wound Closure in Mice with Experimental Diabetes Mellitus [PDF]

, 2000
The purpose of the present study was to examine the effect of electrical stimulation (ES) on the closure of full-thickness excisional wounds in mice with type-1 experimental diabetes mellitus (DM).
Butryn, Anna, Houghton, Pamela E., Kloth, Luther, Thawer, Habiba A.   +3 more
core   +1 more source

Using honey to heal diabetic foot ulcers [PDF]

, 2008
Diabetic ulcers seem to be arrested in the inflammatory/proliferative stage of the healing process, allowing infection and inflammation to preclude healing.
Aaltonen, LA, Ballereau, S, Barclay, E, Broderick, P, Campbell, H, Carvajal-Carmona, LG, Casey, G, Cazier, JB, Chander, I, Cheadle, JP, Conti, D, Deary, I, Dobbins, SE, Domingo, E, Duggan, DJ, Dunlop, MG, Easton, D, Farrington, SM, Frampton, M, Gallinger, S, Gorman, M, Grimes, G, Henrion, M, Hopper, J, Houlston, RS, Jenkins, MA, Jones, AM, Kerr, DJ, Kirac, I, Kovacević, D, Lindblom, A, Liu, T, Lloyd, A, Lubbe, S, Ma, YP, Martin, L, Matsuda, K, Mecklin, JP, Midgley, R, Nakamura, Y, Newcomb, P, Okada, Y, Olver, B, Ooi, LY, Palles, C, Penegar, S, Pharoah, P, Prendergast, J, Renkonen-Sinisalo, L, Rudan, I, Schumacher, F, Semple, C, Shah, M, Smillie, C, Smith, CG, Spain, S, Starr, JM, Tenesa, A, Theodoratou, E, Tomlinson, IP, Vijayakrishnan, J, West, H, Whiffin, N, Zgaga, L   +63 more
core   +2 more sources