Results 81 to 90 of about 996,232 (360)

Hematopoietic (stem) cells—The elixir of life?

FEBS Letters, EarlyView.
The aging of HSCs (hematopoietic stem cells) and the blood system leads to the decline of other organs. Rejuvenating aged HSCs improves the function of the blood system, slowing the aging of the heart, kidney, brain, and liver, and the occurrence of age‐related diseases.
Emilie L. Cerezo, Jonah Anderson, Emilie Dinh Vedrenne, Noël Yeh Martín, Jette Lengefeld   +4 more
wiley   +1 more source

The financial burden of chronic wounds in primary care: A real-world data analysis on cost and prevalence

International Journal of Nursing Studies Advances
Background: Chronic wounds place a substantial clinical and economic burden on health systems and significantly reduce the quality of life of those affected.
Miguel Ángel Díaz-Herrera, Mónica González-Durán, Francisco Javier Rodríguez-Martínez, Gema Tujillo-Flores, Nuria Tuset-Mateu, Jose Verdú-Soriano, Vicente Gea-Caballero, Albert Sanllorente-Melenchón, Jesús Almeda-Ortega, Oriol Cunillera-Puértolas, Mateo Acedo-Anta, José Ramón Martínez-Riera   +11 more
doaj   +1 more source

Microneedle arrays for the treatment of chronic wounds

Expert Opinion on Drug Delivery, 2020
Introduction Chronic wounds are seen frequently in diabetic and bedbound patients. Such skin injuries, which do not heal in a timely fashion, can lead to life-threatening conditions.
Lindsay Barnum, M. Samandari, T. Schmidt, A. Tamayol   +3 more
semanticscholar   +1 more source

The role and implications of mammalian cellular circadian entrainment

FEBS Letters, EarlyView.
At their most fundamental level, mammalian circadian rhythms occur inside every individual cell. To tell the correct time, cells must align (or ‘entrain’) their circadian rhythm to the external environment. In this review, we highlight how cells entrain to the major circadian cues of light, feeding and temperature, and the implications this has for our
Priya Crosby
wiley   +1 more source

Smart Bandage for Monitoring and Treatment of Chronic Wounds.

Small, 2018
Chronic wounds are a major health concern and they affect the lives of more than 25 million people in the United States. They are susceptible to infection and are the leading cause of nontraumatic limb amputations worldwide.
P. Mostafalu, A. Tamayol, R. Rahimi, M. Ochoa, A. Khalilpour, Gita Kiaee, Iman K. Yazdi, S. Bagherifard, M. Dokmeci, B. Ziaie, S. Sonkusale, A. Khademhosseini   +11 more
semanticscholar   +1 more source

The role of histone modifications in transcription regulation upon DNA damage

FEBS Letters, EarlyView.
This review discusses the critical role of histone modifications in regulating gene expression during the DNA damage response (DDR). By modulating chromatin structure and recruiting repair factors, these post‐translational modifications fine‐tune transcriptional programmes to maintain genomic stability.
Angelina Job Kolady, Siyao Wang
wiley   +1 more source

Assessment of applicability of Ganga Hospital Score in the management of open tibia fracture

Bone & Joint Open
Aims: Open fractures of the tibia encompass a wide spectrum of injuries, posing multiple challenges for treating surgeons. This study evaluates the Ganga Hospital Open Injury Severity Score (GHOISS) in predicting the outcomes of open tibia fractures in ...
Innocent Kwizera, Jean C. Byiringiro, J. C. A. Ingabire, Emmanuel Murwanashyaka, Jean L. Mwizerwa   +4 more
doaj   +1 more source

Periodontal Dressing: A Review Article

Journal of Dental Research, Dental Clinics, Dental Prospects, 2013
The purpose of this paper was to review the commercially available periodontal dressings, their physical and chemical properties, biocompatibility and therapeutic effects.
Zahra Baghani, Mahdi Kadkhodazadeh
doaj   +1 more source

The humanistic and economic burden of chronic wounds: a protocol for a systematic review

Systematic Reviews, 2017
BackgroundChronic non-healing wounds present a substantial economic burden to healthcare system; significant reductions in quality of life for those affected, and precede often serious events such as limp amputations or even premature deaths. This burden
K. Järbrink, G. Ni, H. Sönnergren, A. Schmidtchen, Caroline Pang, R. Bajpai, J. Car   +6 more
semanticscholar   +1 more source

Integration of circadian and hypoxia signaling via non‐canonical heterodimerization

FEBS Letters, EarlyView.
CLOCK, BMAL1, and HIFs are basic helix‐loop‐helix and Per‐Arnt‐Sim domain (bHLH‐PAS) proteins, which function as transcription factors. bHLH‐PAS proteins are designated in two classes. Many class I proteins are regulated by environmental signals via their PAS domains, but such signals have not been identified for all.
Sicong Wang, Katja A. Lamia
wiley   +1 more source