Results 101 to 110 of about 1,971,412 (267)

Galinstan Liquid Metal/Polyurethane Composite as a Multifunctional Stretchable Electrode and Piezoresistive Strain Sensor With Minimal Drift

Advanced Materials Technologies, EarlyView.
Liquid metal additives are processed in elastomer host resulting in highly conductive and stretchable composites. The material functions as a piezoresistive sensor with minimal drift, low stiffness, and enhanced operating range. The film can replace wires to charge a mobile phone at ∼350% strain and monitors bodily motion in real‐time via a portable ...
Patryk Wojciak, Neeraj Kumar, Toby Hallam, Shayan Seyedin   +3 more
wiley   +1 more source

Selective Reflection of Chiral Ferroelectric Nematic Liquid Crystals Tuned by Electric Field Along the Helix Axis

Advanced Optical Materials, EarlyView.
It is demonstrated that in chiral ferroelectric nematic liquid crystals sandwiched between electrically conducting transparent plates, the reflection color can be reversibly tuned by electric fields applied along the helix axis. The proposed theoretical model, assuming field‐induced coiling of the helix axis, accounts for all observations.
Md Sakhawat Hossain Himel, Rohan Dharmarathna, James T. Gleeson, Robert J. Twieg, Samuel Sprunt, Antal Jákli   +5 more
wiley   +1 more source

Tailoring Vascular‐Immune Homeostasis via Manganese‐DNA Complex‐Armed Immunogenic Extracellular Vesicles for Pancreatic Cancer Immunotherapy

Advanced Science, EarlyView.
This study demonstrates that Mn2⁺–tumor DNA complexes encapsulated in dendritic cell (DC)– derived immunogenic extracellular vesicles (EVDC@Mn‐DNA) act as a DC‐specific cGAS– STING activator. EVDC@Mn‐DNA treatment enhances intratumoral DC activation, improves tumor vascular function, promotes CD8⁺ T cell activity, and suppresses pancreatic tumor growth,
Xue Jiang, Lihuan Shang, Xiaochun Chen, Xiangzhan Kong, Xiaojuan Wang, Linjia Jiang, Huiying Zhao, Yafeng Zhu, Cheng Huang, Shiyi Deng, Rui Zhang, Minghui Wang, Haoming Lin, Ping‐Pui Wong   +13 more
wiley   +1 more source

PD‐1 Inhibits CD4+ TRM‐Mediated cDC1 Mobilization via Suppressing JAML in Human NSCLC

Advanced Science, EarlyView.
CD4+ tissue‐resident memory T cells (TRMs) in non‐small cell lung cancer recruit conventional type 1 dendritic cells via XCL1‐XCR1 signaling, orchestrating antitumor immunity. The costimulatory molecule JAML is essential for this process. PD‐1 blockade restores JAML expression and cDC1 mobilization, while JAML agonists synergize with anti‐PD‐1 therapy,
Zheyu Shao, Qinyuan Liu, Zhongwei Xin, Zhiyao Zhou, Mingjie Lin, Di Chen, Zhixing Hao, Yongyuan Chen, Wenxuan Wu, Shuyang Zhang, Xiaoke Chen, Xia Xu, Jinfan Li, Wei Lin, Yuhao Lu, Dang Wu, Pin Wu   +16 more
wiley   +1 more source

Natural Products Inspired Scaffold Diversification Leads to Unnatural Molecular Warhead and Covalent Strategy to Modulating Protein Function through Electrophilic Bromine Transfer

Advanced Science, EarlyView.
We report a new thiolate‐reactive α,α‐gem‐dibromo lactam warhead that activates transcription factor Nrf2 and demonstrates anti‐inflammatory activities, which have implications in cancer, neurodegeneration, and cardiovascular diseases. RNA‐seq illuminated detailed transcriptional profiles, and chemical reactions with cysteine‐containing compounds ...
Beau R. Brummel, Sofia Kokkaliari, Qiwen Gao, Jinjing Chen, Larissa Costa de Almeida, Srinivasarao Tenneti, Derek A. Leas, Eli Levit, Lewis S. Alexander, Khalil A. Abboud, Pingrong Wei, Michael D. Cameron, James R. Rocca, Ranjala Ratnayake, Donna D. Zhang, Hendrik Luesch, Robert W. Huigens III   +16 more
wiley   +1 more source

Effects of Input Consistency on Children’s Cross-Situational Statistical Learning of Words and Morphophonological Rules

Languages
Children learn linguistic structures from the input they receive. Their learning may depend on several factors such as children’s sensitivity to structure in the input, prior language experience, and the consistency of linguistic structures in the input.
Marica Savarino, Merel van Witteloostuijn, Josje Verhagen, Judith Rispens, Imme Lammertink   +4 more
doaj   +1 more source

Fibrates Inhibit PLTP‐induced M2 Macrophage Infiltration and Increase the Sensitivity of Hepatocellular Carcinoma to ICIs

Advanced Science, EarlyView.
Phospholipid transfer protein(PLTP) plays a critical role in forming a complex with kinase A (AURKA) and P65. This interaction facilitates phosphorylation of P65 at Ser536, leading to the activation of the NF‐κB signaling pathway. Ultimately, this leads to the upregulation of downstream cytokines, including IL‐6, IL‐8, and CSF‐1, which promotes M2 ...
Xinyue Liang, Yaning Li, Jianxun Cai, Lisi Luo, Pengfei Yang, Yutong Chen, Jiancong Zhou, Yan Zeng, Jiaping Yu, Weiyu Zhang, Wenzheng Pang, Yufang Li, Chunhua Wen, Jian Li, Linjuan Zeng   +14 more
wiley   +1 more source

Establishment of the International Criminal Tribunal in the Former Yugoslavia (ICTY): Dealing with the “War Raging at the Heart of Europe”

Romanian Journal of European Affairs, 2011
Much has been written on the question of disintegration of the former Yugoslavia and the conflict that followed. A lot of scholarly attention was devoted to the analysis of the reasons of the Yugoslav war, political, military, psychological and other ...
Galina Nelaeva
doaj  

NPM1 Mediates mRNA Sorting into Extracellular Vesicles via Specific RNA Motif Binding and Phase Separation

Advanced Science, EarlyView.
NPM1 selectively sorts specific mRNAs into extracellular vesicles (EVs) by recognizing RNA motifs and forming phase‐separated condensates. These mRNA cargos—including EGFR—are then loaded via multivesicular bodies. This active sorting pathway, validated in EVs derived from both lung cancer cells and patient serum, reveals a specific mechanism for ...
Kaixiang Zhang, Gaoge Sun, Xiangzheng Liu, Shuai Zuo, Pengyuan Wang, Boxiao Zhan, Zhi John Lu, Hang Yin, Ying Zhang   +8 more
wiley   +1 more source

Unravelling non-communicable diseases among pregnant women in a lower-middle-income country and the feto-maternal outcomes: a descriptive cross-sectional study

BMJ Open
Objectives This study aimed to determine the prevalence of non-communicable diseases (NCDs) among pregnant women in Sri Lanka and examine the association between NCDs and maternal and fetal outcomes.Design A hospital-based, descriptive cross-sectional ...
Anne Thushara Matthias, Probhodana Ranaweera, Hiruni Abeysinghe, R Prathapan, Shanilka Marious, Madura Jayawardena, Rasika Herath, Rukshan Cleophas Fernandopulle, Ajith Fernando, Dhammike Silva, Shameera Ruwan Chamara, Shamini Prathapan   +11 more
doaj   +1 more source