Results 121 to 130 of about 4,022,617 (298)
Molecular Oncology, EarlyView.The proposed mechanism of action for the CDK12/13 inhibitor and cyclin K degrader, CT7439. CDK12/13 inhibition interrupts transcription elongation, leading to increased DNA damage that results in cell death. This agent is a potentially novel treatment option for patients with colorectal cancer. Created in BioRender. Cyclin‐dependent kinase (CDK) 12 and
Wylie K. Watlington +10 more
wiley +1 more source
Molecular Oncology, EarlyView.Drug resistance limits treatment success in a subset of lung cancers driven by ROS1 gene alterations. Using patient‐derived cells and computer simulations, we studied three key mutations and how they affect five targeted drugs. The mutations reduced drug effectiveness in different ways by altering protein structure and behavior.
Farhan Ul Haq +8 more
wiley +1 more source
Molecular Oncology, EarlyView.Circulating microRNAs as biomarkers of cachexia and sex‐specific cancer in senior dogs. In 25 client‐owned dogs, four circulating miRNAs (miR‐15a, miR‐15b, miR‐16, miR‐140) were downregulated in cachexia, with miR‐16 the strongest individual biomarker (AUC = 0.899).
Soon‐Seok Park +6 more
wiley +1 more source
This study aims to show the influence of Learning Methods and Emotional Intelligence on the Ability to Write Students' English Narrative Texts. The research hypotheses tested include: 1).Effect of Learning Methods on the Ability to Write English ...
Suwardin Mbulu
core
An Analysis of Students’ Writing Ability in AI-Assisted Writing
International Journal of Language, Education, and LiteratureThe integration of Artificial Intelligence (AI) tools in writing instruction has garnered widespread attention; however, empirical evidence on the actual quality of student writing produced with AI assistance remains limited. This study aims to examine students' writing ability in AI-assisted writing products.
null Ulfa Haera +2 more
openaire +1 more source
Cancer‐associated mutations in endometriosis reframe a benign disease through molecular oncology
Molecular Oncology, EarlyView.This review aims to comprehensively analyse cancer‐associated somatic mutations (CAMs) present in endometriotic lesions, emphasizing their biological roles, spatial distribution and implications for translational applications in medicine. By contextualizing a benign state within a genomic framework, this analysis seeks to establish its value as a ...
Clarissa Mujacic +15 more
wiley +1 more source
Design of half-select free 12T SRAM cell with high performance for health care applications
e-Prime: Advances in Electrical Engineering, Electronics and EnergyStatic Random Access Memory (SRAM) plays a crucial role in applications related to health like Body Area Networks (BANs) which require increased battery lives for the sensor nodes in BANs.
Manoj Kumar R․ +1 more
doaj +1 more source
Molecular Oncology, EarlyView.LUNAR is a liver‐specific long noncoding RNA (lncRNA) that is highly expressed in normal liver but becomes epigenetically silenced in hepatocellular carcinoma through promoter hypermethylation. Loss of LUNAR is associated with NOTCH activation, epithelial–mesenchymal transition, and metastasis, whereas restoring LUNAR restrains metastatic progression ...
Se Ha Jang +9 more
wiley +1 more source
Repeat studied letters. Securing the ability to write letters examined. Development of coherent speech [PDF]
, 2016 У статті поданий урок письма (1 клас) на тему: "Повторення вивчених букв. Закріплення вміння писати вивчені букви. Розвиток зв'язного мовлення"В статье представлен урок письма (1 класс) по теме: "Повторение изученных букв.
Комендант, Ольга
core +1 more source
Molecular Oncology, EarlyView.This study identifies somatostatin receptor 4 (Sstr4) as a critical tumor suppressor against skin and head/neck cancers (HNSCC, cSCC, and BCC). The loss of Sstr4 removes a check on cell growth, causing hyperactivation of the MAPK‐ERK signaling pathway (↑).
Ali Taqvi +6 more
wiley +1 more source